Cooper E H
Biomed Pharmacother. 1985;39(4):165-6.
Neuron specific enolase (NSE) has been demonstrated to be a marker for tumours of neuroendocrine origin. Serum NSE levels have been shown by several groups to be of help in the identification of advanced small cell lung cancers and neuroblastoma. The lack of sensitivity to small tumour burdens and lack of specificity of small increments above normal restricts the test as a diagnostic aid in early stage disease. The main use would seem to be in the monitoring of chemotherapy and follow up after completing treatment as sequential measurements enable relatively small changes in level to be interpreted.
神经元特异性烯醇化酶（NSE）已被证明是神经内分泌起源肿瘤的标志物。多个研究小组表明，血清NSE水平有助于识别晚期小细胞肺癌和神经母细胞瘤。对小肿瘤负荷缺乏敏感性以及高于正常水平的小幅升高缺乏特异性，限制了该检测作为早期疾病诊断辅助手段的应用。其主要用途似乎在于化疗监测以及治疗完成后的随访，因为连续测量能够解读水平上相对较小的变化。
