Rapellino M, Pecchio F, Cunazza M, Baldi S, Adamo M R, Casadio C, Faga C, Baldi C, Oliaro A, Albertino B
Ospedale Maggiore S. Giovanni Battista, Torino, Servizio di Fisiopatologia Respiratoria e Broncologia.
Minerva Med. 1988 Dec;79(12):1051-2.
Neurone-specific enolase, a serum marker of neuroendocrine tumours has been determined in small-cell anaplastic bronchial carcinomas, in typical and atypical carcinoid. The marker presents good sensitivity in small-cell tumours and in atypical carcinoids, while blood levels are within normal limits in cases of typical carcinoid. The low serum levels of neurone-specific enolase found in typical carcinoid suggest a failure of the enzyme to express itself in the circulation owing to the poor or lack of cellular necrosis.
已经在小细胞间变性支气管癌、典型类癌和非典型类癌中测定了神经特异性烯醇化酶，它是神经内分泌肿瘤的一种血清标志物。该标志物在小细胞肿瘤和非典型类癌中具有良好的敏感性，而在典型类癌病例中，血液水平在正常范围内。在典型类癌中发现的神经特异性烯醇化酶血清水平较低，这表明由于细胞坏死较少或缺乏，该酶未能在循环中表达。
