Cooper S J, Kelly J G, King D J
Br J Psychiatry. 1985 Jul;147:23-9. doi: 10.1192/bjp.147.1.23.
Platelet alpha 2-and lymphocyte beta 2-adrenoceptor densities, plasma noradrenaline and serum cortisol were measured before, during and one week after a course of EEG-monitored electroconvulsive therapy, in nine depressed patients. A 50% fall in Hamilton Depression Rating scores occurred after a fairly consistent total seizure time, regardless of the amount of ECT given. Platelet alpha 2-adrenoceptor densities showed a statistically significant fall after three ECTs, but were unchanged after the full course of ECT and were independent of clinical change. Lymphocyte beta 2-adrenoceptor densities were unaltered. Plasma noradrenaline concentrations were initially high, and fell with ECT in a manner paralleling clinical recovery. Plasma noradrenaline may be a more useful index of central changes during antidepressant treatment than peripheral blood cell receptor densities.
对9名抑郁症患者在接受脑电图监测的电休克治疗疗程之前、治疗期间及治疗后一周，测量了血小板α2 - 肾上腺素能受体密度、淋巴细胞β2 - 肾上腺素能受体密度、血浆去甲肾上腺素和血清皮质醇。无论给予的电休克治疗量如何，在癫痫发作总时长相当一致后，汉密尔顿抑郁量表评分下降了50%。血小板α2 - 肾上腺素能受体密度在3次电休克治疗后出现了具有统计学意义的下降，但在整个电休克治疗疗程后没有变化，且与临床变化无关。淋巴细胞β2 - 肾上腺素能受体密度未改变。血浆去甲肾上腺素浓度最初较高，并随着电休克治疗以与临床恢复平行的方式下降。与外周血细胞受体密度相比，血浆去甲肾上腺素可能是抗抑郁治疗期间中枢变化更有用的指标。
