García-Sevilla J A, Zis A P, Hollingsworth P J, Greden J F, Smith C B
Arch Gen Psychiatry. 1981 Dec;38(12):1327-33. doi: 10.1001/archpsyc.1981.01780370029003.
The specific binding of tritiated (3H)-clonidine, an alpha 2-adrenergic receptor agonist, to platelet membranes was measured in normal subjects and in patients with major depressive disorder. The number of platelet alpha 2-adrenergic receptors from the depressed group was significantly higher than that found in platelets obtained from the control population. Treatment with tricyclic antidepressant drugs led to significant decreases in the number of platelet alpha 2-adrenergic receptors. These results support the hypothesis that the depressive syndrome is related to an alpha 2-adrenergic receptor supersensitivity and that the clinical effectiveness of tricyclic antidepressant drugs is associated with a decrease in the number of these receptors.
在正常受试者和重度抑郁症患者中，测定了α2 - 肾上腺素能受体激动剂氚化（3H）可乐定与血小板膜的特异性结合。抑郁症组血小板α2 - 肾上腺素能受体的数量显著高于对照组人群血小板中的数量。三环类抗抑郁药治疗导致血小板α2 - 肾上腺素能受体数量显著减少。这些结果支持了以下假设：抑郁综合征与α2 - 肾上腺素能受体超敏反应有关，且三环类抗抑郁药的临床疗效与这些受体数量的减少有关。
