Jackson A, Cooper S J
Brain Res Bull. 1985 Oct;15(4):391-6. doi: 10.1016/0361-9230(85)90007-3.
There is increasing evidence to suggest that kappa opiate receptors may be importantly involved in the mediation of feeding responses in the rat. A series of experiments is reported in which the effects of four kappa receptor agonists (ethylketocyclazocine, U-50,488H, tifluadom, bremazocine) on the consumption of a highly palatable diet were investigated. Under one condition, non-deprived male rats were administered drug treatments before a 30 min feeding test. Bremazocine (0.1 mg/kg) and ethylketocyclazocine (3.0 mg/kg) both significantly decreased the level of food consumption. In contrast, U-50,488H and tifluadom each produced significant increases in food intake. In a second condition, non-deprived male rats were first allowed to consume some of the palatable diet to achieve partial satiation, prior to the administration of the drug treatments. In this case, evidence for hyperphagic effects of all four kappa agonists was obtained, within the first 30 min access to the palatable diet. Thus, hyperphagia occurred with 0.01 mg/kg bremazocine and 0.1 mg/kg ethylketocyclazocine. We conclude that some kappa agonists have mixed stimulant/inhibitory effects on food intake, whereas others are more consistent in producing hyperphagia. In neither condition did morphine (0.3-10.0 mg/kg) show any hyperphagic effect. Our data support an involvement of kappa opiate receptors in mechanisms which control palatable food consumption in non-deprived rats.
越来越多的证据表明，κ阿片受体可能在介导大鼠的进食反应中起重要作用。本文报道了一系列实验，研究了四种κ受体激动剂（乙基酮环唑辛、U-50,488H、替氟朵、布瑞马唑辛）对高适口性食物摄入量的影响。在一种情况下，未禁食的雄性大鼠在30分钟进食测试前接受药物治疗。布瑞马唑辛（0.1毫克/千克）和乙基酮环唑辛（3.0毫克/千克）均显著降低了食物摄入量。相比之下，U-50,488H和替氟朵各自显著增加了食物摄入量。在第二种情况下，未禁食的雄性大鼠在接受药物治疗前，先让它们食用一些适口性食物以达到部分饱腹感。在这种情况下，在最初30分钟接触适口性食物期间，获得了所有四种κ激动剂产生贪食作用的证据。因此，0.01毫克/千克布瑞马唑辛和0.1毫克/千克乙基酮环唑辛出现了贪食现象。我们得出结论：一些κ激动剂对食物摄入量有混合的刺激/抑制作用，而其他一些则在产生贪食方面更具一致性。在两种情况下，吗啡（0.3 - 10.0毫克/千克）均未显示出任何贪食作用。我们的数据支持κ阿片受体参与了控制未禁食大鼠适口性食物消耗的机制。
