Department of Internal Medicine, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Korea.
Department of Rehabilitation Medicine, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Korea.
J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1062-1069. doi: 10.1093/gerona/glx188.
The aims of this study were to investigate the longitudinal changes in muscle and bone with aging, and to clarify the muscle-bone relationships.
In a community-based prospective study, a total of 172 men and 165 women aged ≥ 65 years who had performed body composition analysis and bone mineral density (BMD) by dual-energy x-ray absorptiometry at baseline and 5-year follow-up evaluations were included.
The rate of BMD loss in total hip was significantly associated with baseline legs lean mass and loss rate of leg strength, but not with the rate of muscle mass losses in men (r = .205 in leg lean mass, r = .170 in loss rate of leg muscle strength, p < .05 respectively). However, in women, it was significantly correlated with the rate of leg lean mass loss, but not with baseline values, and the rate of loss in leg muscle strength (r = .169 in the rate of loss in leg lean mass, r = .246 in the rate of loss in leg muscle strength, p < .05 respectively). In multivariate analyses, the rates of decrease in leg muscle strength showed independent positive associations with loss in total hip BMD in both men and women (β = 0.023 for men and β = 0.045 for women, both p < .05 respectively).
There was a gender difference in muscle and bone mass changes with aging, and muscle-bone interactions as well. However, a longitudinal change in muscle strength was the most significant independent factor associated with bone loss for both genders.
本研究旨在探讨肌肉和骨骼随年龄的纵向变化，并阐明肌肉-骨骼关系。
在一项基于社区的前瞻性研究中，共纳入了 172 名男性和 165 名年龄≥65 岁的女性，他们在基线和 5 年随访时均进行了体成分分析和双能 X 线吸收法测定骨密度。
总髋部 BMD 丢失率与基线时腿部瘦体重和腿部力量下降率显著相关，但与男性肌肉质量下降率无关（腿部瘦体重 r =.205，腿部肌肉力量下降率 r =.170，均 p <.05）。然而，在女性中，它与腿部瘦体重丢失率显著相关，但与基线值和腿部肌肉力量丢失率无关（腿部瘦体重丢失率 r =.169，腿部肌肉力量丢失率 r =.246，均 p <.05）。多元分析显示，男性和女性的腿部肌肉力量下降率与总髋部 BMD 丢失率呈独立正相关（男性β = 0.023，女性β = 0.045，均 p <.05）。
随着年龄的增长，肌肉和骨量的变化存在性别差异，肌肉-骨骼的相互作用也存在性别差异。然而，肌肉力量的纵向变化是与两性骨丢失最显著的独立相关因素。
