Awounfack Charline Florence, Mvondo Marie Alfrede, Zingue Stéphane, Ateba Sylvin Benjamin, Djiogue Sefirin, Megnekou Rosette, Tantoh Ndinteh Derek, Njamen Dieudonné
Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
Laboratory of Animal Physiology and Phytopharmacology, Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Medicines (Basel). 2018 Jul 7;5(3):73. doi: 10.3390/medicines5030073.
Despite the wide use of leaves of (Cecropiaceae) in several African countries including Cameroon as food and against amenorrhea and female infertility, it has never been tested for this purpose. Using immature female Wistar rats, the impact of on the sexual maturation parameters (vaginal opening, ovarian relative weight and follicle maturation, gonadotropins and ovarian hormones serum levels) and fertility index has been evaluated through a 30-day oral administration of aqueous and methanol extracts of leaves at the doses of 20, 110 and 200 g/kg/day. Aqueous extract increased the ovarian relative weight ( < 0.001), progesterone ( < 0.001) and gonadotropins ( < 0.001) serum levels, and induced the maturation of ovarian follicles. The methanol extract additionally induced an early vaginal opening ( < 0.001), uterine growth ( < 0.01) and increased estradiol ( < 0.001) serum levels. The fertility index generally increased following treatments, while the gestation rate remained almost unaffected except at the highest tested dose of where lowest values were observed. Globally, induced an early puberty onset and an increased fertility rate validating at least in part its traditional use for female infertility.
尽管在包括喀麦隆在内的几个非洲国家，人们广泛使用（荨麻科）植物的叶子作为食物，并用于治疗闭经和女性不孕症，但从未针对此用途进行过测试。使用未成熟的雌性Wistar大鼠，通过以20、110和200克/千克/天的剂量口服叶子的水提取物和甲醇提取物30天，评估了其对性成熟参数（阴道开口、卵巢相对重量和卵泡成熟、促性腺激素和卵巢激素血清水平）和生育指数的影响。水提取物增加了卵巢相对重量（P<0.001）、孕酮（P<0.001）和促性腺激素（P<0.001）的血清水平，并诱导了卵巢卵泡的成熟。甲醇提取物还诱导了早期阴道开口（P<0.001）、子宫生长（P<0.01）并增加了雌二醇（P<0.001）的血清水平。治疗后生育指数总体上有所增加，而妊娠率几乎不受影响，除了在最高测试剂量下观察到最低值。总体而言，该植物诱导了青春期提前开始和生育率增加，至少部分验证了其在女性不孕症方面的传统用途。
