Oyedokun Precious Adeoye, Ashonibare Victory Jesutoyosi, Fabrael Fidelis Batale, Akhigbe Tunmise Maryanne, Akangbe Marvelous Dasola, Akhigbe Roland Eghoghosoa
Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Nigeria.
Cell Biochem Biophys. 2025 Mar;83(1):327-343. doi: 10.1007/s12013-024-01565-6. Epub 2024 Oct 6.
Adaptogens, comprising plants and mushrooms, modulate the immune system, energy balance, and various physiological processes, including reproduction. Despite their potential benefits, the impact of adaptogens on reproductive function remains understudied. This review examines the effects of common adaptogens on male and female reproductive functions, highlighting their regulation of neuro-endocrine-immune interactions crucial for reproduction. While existing literature reveals varying impacts on reproductive function, most adaptogens exhibit beneficial effects, modulating neuroimmunology and promoting gonadal steroidogenesis, spermatogenesis, and folliculogenesis through direct mechanisms or suppression of oxidative stress and inflammation. Further experimental research is necessary to elucidate the mechanisms of action of adaptogens, which would significantly advance the management of reproductive disorders and other diseases. Validating these findings in clinical trials is also essential.
适应原包括植物和蘑菇，可调节免疫系统、能量平衡以及包括生殖在内的各种生理过程。尽管具有潜在益处，但适应原对生殖功能的影响仍未得到充分研究。本综述探讨了常见适应原对男性和女性生殖功能的影响，强调了它们对生殖至关重要的神经 - 内分泌 - 免疫相互作用的调节作用。虽然现有文献显示对生殖功能有不同影响，但大多数适应原表现出有益作用，通过直接机制或抑制氧化应激和炎症来调节神经免疫学并促进性腺类固醇生成、精子发生和卵泡发生。需要进一步的实验研究来阐明适应原的作用机制，这将显著推进生殖障碍和其他疾病的管理。在临床试验中验证这些发现也至关重要。
