Vincent Audrey, Souberbielle Jean-Claude, Brauner Raja
Fondation Ophtalmologique Adolphe de Rothschild and Université Paris Descartes, 75940, Paris, France.
Hôpital Necker-Enfants Malades, Service d'Explorations Fonctionnelles, Assistance Publique-Hôpitaux de Paris, 75743, Paris, France.
BMC Pediatr. 2018 Jul 9;18(1):224. doi: 10.1186/s12887-018-1194-8.
The bone markers bone alkaline phosphatase (BAP) and C-terminal telopeptide of type I collagen crosslinks (CTX) are correlated with growth rate during normal puberty. The objective of this study was to evaluate the relationship between the serum concentrations of BAP and CTX and growth evolution in girls with idiopathic central precocious puberty (CPP) to help predict adult height.
A retrospective single-center study was conducted in 74 girls with CPP for whom a serum sample at initial evaluation was available to retrospectively measure BAP and CTX concentrations; 66.2% of them were untreated.
The serum BAP concentrations showed significant positive correlations with height in standard deviations (SDS) at the initial evaluation (n = 62; r = 0.31; p = 0.015) and with the difference between bone and chronological ages (n = 61; r = 0.39; p = 0.002). BAP was also positively correlated with adult height as measured in both cm and SDS in untreated patients (n = 19; r = 0.58; p = 0.009). The serum CTX concentrations showed significant positive correlations with growth rate the year before the initial evaluation as measured in both cm and SDS (n = 65; r = 0.34; p = 0.006).
This study revealed significant correlations of serum BAP and CTX concentrations with growth evolution in girls with CPP. The high positive correlation between serum BAP and adult height in untreated girls suggests that BAP can possibly be used to optimize models of adult height prediction in girls with CPP.
骨标志物骨碱性磷酸酶（BAP）和I型胶原交联C末端肽（CTX）与正常青春期的生长速率相关。本研究的目的是评估特发性中枢性性早熟（CPP）女孩血清中BAP和CTX浓度与生长发育的关系，以帮助预测成年身高。
对74例CPP女孩进行回顾性单中心研究，这些女孩在初始评估时有血清样本可用于回顾性测量BAP和CTX浓度；其中66.2%未接受治疗。
血清BAP浓度在初始评估时与身高标准差（SDS）呈显著正相关（n = 62；r = 0.31；p = 0.015），与骨龄和实际年龄之差呈正相关（n = 61；r = 0.39；p = 0.002）。在未治疗的患者中，BAP与以厘米和SDS衡量的成年身高也呈正相关（n = 19；r = 0.58；p = 0.009）。血清CTX浓度与初始评估前一年的生长速率呈显著正相关，以厘米和SDS衡量（n = 65；r = 0.34；p = 0.006）。
本研究揭示了CPP女孩血清BAP和CTX浓度与生长发育之间存在显著相关性。未治疗女孩血清BAP与成年身高之间的高度正相关表明，BAP可能可用于优化CPP女孩成年身高预测模型。
