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Radiotoxicity of 11C-methionine measured by the accumulation of DNA strand breaks in mammalian cells.

作者信息

Stålnacke C G, Sundell-Bergman S, Halldin C, Långström B

出版信息

Eur J Nucl Med. 1985;11(5):166-70. doi: 10.1007/BF00251368.

DOI:10.1007/BF00251368
PMID:2998797
Abstract

The radiotoxic effects of L-[methyl-11C] methionine were estimated by measuring the accumulation of DNA strand breaks. CHO, Chinese-hamster cells, were incubated in 11C-methionine-containing medium for 60 min at 37 degrees C. The number of unrepaired DNA strand breaks was then examined by the DNA-unwinding method. For comparison, cells were also externally irradiated under similar conditions with gamma radiation (137Cs) or positrons (11C). The relative biological effectiveness of 11C-methionine was estimated to be about 1.

摘要

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本文引用的文献

1
Repairable and unrepairable DNA strand breaks induced by decay of 3H and 125I incorporated into DNA of mammalian cells.由掺入哺乳动物细胞DNA中的³H和¹²⁵I衰变诱导产生的可修复和不可修复的DNA链断裂。
Radiat Environ Biophys. 1980;18(4):239-48. doi: 10.1007/BF01324266.
2
DNA double strand breaks in Ehrlich ascites tumour cells at low doses of x-rays. II. Can cell death be attributed to double strand breaks?低剂量X射线照射下艾氏腹水瘤细胞中的DNA双链断裂。II. 细胞死亡能归因于双链断裂吗？
Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Sep;42(3):329-38. doi: 10.1080/09553008214551241.
3
Measurement of the kinetics of DNA double strand break repair in Ehrlich ascites tumour cells using the unwinding method.
使用解旋法测量艾氏腹水瘤细胞中DNA双链断裂修复的动力学
Int J Radiat Biol Relat Stud Phys Chem Med. 1980 Sep;38(3):335-47. doi: 10.1080/09553008014551691.
4
Short-lived radionuclides in nutritional physiology. A model study with L-[Me-11C]methionine in the pig.营养生理学中的短寿命放射性核素。用L-[甲基-¹¹C]蛋氨酸在猪身上进行的模型研究。
Br J Nutr. 1982 May;47(3):537-45. doi: 10.1079/bjn19820065.
5
Thallium-201: an experimental and a theoretical radiobiological approach to dosimetry.铊-201：剂量测定的实验与理论放射生物学方法
J Nucl Med. 1983 Dec;24(12):1164-75.
6
Some considerations of the transmutation effect due to radioactive isotopes incorporated in cells and on the irradiation effect.关于细胞中所含放射性同位素的嬗变效应以及辐照效应的一些思考。
Int J Radiat Biol Relat Stud Phys Chem Med. 1983 Jan;43(1):95-101. doi: 10.1080/09553008314550091.
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J Nucl Med. 1971 Mar:Suppl 5:5-23.