d'Argy R, Ullberg S, Stålnacke C G, Långström B
Int J Appl Radiat Isot. 1984 Feb;35(2):129-34. doi: 10.1016/0020-708x(84)90196-0.
This paper reports that it is possible to obtain good autoradiographic pictures of a 11C-labelled compound ([11C]methionine) in spite of the short half-life of 20 min by modifying the whole-body autoradiographic (WBA) technique. Double radionuclide autoradiography was performed by utilizing the great difference between the half-lives of 11C and 14C or 35S. The first exposure resulted entirely from 11C, and the second exposure the day after from 14C or 35S, respectively. Satisfactory blackening of the film was obtained by a mean radioactivity of 1.6 X 10(6) disintegrations/cm2 during the exposure. The 11C-WBA technique apparently provides a useful tool in distribution studies on animals, which is valuable in the interpretation of positron emission tomography images of the same 11C-compound.
本文报道，尽管(^{11}C)标记化合物（([^{11}C])蛋氨酸）半衰期仅20分钟，但通过改进全身放射自显影（WBA）技术仍有可能获得良好的放射自显影图片。利用(^{11}C)与(^{14}C)或(^{35}S)半衰期的巨大差异进行双放射性核素放射自显影。第一次曝光完全由(^{11}C)引起，第二次曝光在一天后分别由(^{14}C)或(^{35}S)引起。曝光期间平均放射性为(1.6×10^{6})次衰变/平方厘米时，胶片获得了令人满意的黑化效果。(^{11}C - WBA)技术显然为动物分布研究提供了一种有用的工具，这对于解释同一(^{11}C)化合物的正电子发射断层扫描图像很有价值。
