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一名患有冷吡啉相关周期性综合征的青少年患者出现结节性红斑。

Erythema nodosum in an adolescent patient with cryopyrin-associated periodic syndrome.

作者信息

Chan Linda, Campbell Dianne E, Ming Andrew G

机构信息

Concord Repatriation General Hospital Concord NSW Australia.

Clinical Immunology and Allergy The Children's Hospital at Westmead Westmead NSW Australia.

出版信息

Clin Case Rep. 2018 May 15;6(7):1241-1245. doi: 10.1002/ccr3.1578. eCollection 2018 Jul.

DOI:10.1002/ccr3.1578
PMID:29988644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6028369/
Abstract

Cryopyrin-associated periodic syndrome (CAPS) is a monogenetic auto-inflammatory disorder with systemic manifestations. Innate immune system aberrance is seen in both CAPS and erythema nodosum and this case may point to a previously unknown association. In pediatric patients with EN and systemic features, the possibility of underlying CAPS should be considered.

摘要

冷吡啉相关周期性综合征（CAPS）是一种具有全身表现的单基因自身炎症性疾病。CAPS和结节性红斑均存在先天性免疫系统异常，该病例可能提示一种此前未知的关联。对于有结节性红斑及全身特征的儿科患者，应考虑潜在CAPS的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d9/6028369/223c599ab3a2/CCR3-6-1241-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d9/6028369/02582d181732/CCR3-6-1241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d9/6028369/7b0c3957ad82/CCR3-6-1241-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d9/6028369/223c599ab3a2/CCR3-6-1241-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d9/6028369/02582d181732/CCR3-6-1241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d9/6028369/7b0c3957ad82/CCR3-6-1241-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d9/6028369/223c599ab3a2/CCR3-6-1241-g003.jpg

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Skin symptoms as diagnostic clue for autoinflammatory diseases.皮肤症状作为自身炎症性疾病的诊断线索。
An Bras Dermatol. 2017 Jan-Feb;92(1):72-80. doi: 10.1590/abd1806-4841.20175208.
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Autoinflammatory Skin Disease: A Review of Concepts and Applications to General Dermatology.自身炎症性皮肤病：概念综述及其在普通皮肤科的应用
Dermatology. 2016;232(5):534-540. doi: 10.1159/000449526. Epub 2016 Nov 22.
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Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS).Cryopyrin 相关周期性综合征（CAPS）的诊断标准。
Ann Rheum Dis. 2017 Jun;76(6):942-947. doi: 10.1136/annrheumdis-2016-209686. Epub 2016 Oct 4.
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Cryopyrin-associated periodic syndrome in Australian children and adults: Epidemiological, clinical and treatment characteristics.澳大利亚儿童和成人中的冷吡啉相关周期性综合征：流行病学、临床及治疗特征
J Paediatr Child Health. 2016 Sep;52(9):889-95. doi: 10.1111/jpc.13270.
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Int J Dermatol. 2016 May;55(5):e289-94. doi: 10.1111/ijd.13212. Epub 2016 Feb 24.
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