灰黄霉素酸的生物学特性，一种带有腺嘌呤基团的环磷酸腺苷磷酸二酯酶抑制剂。
Biological properties of griseolic acid, a cyclic AMP phosphodiesterase inhibitor with an adenine group.
作者信息
Iijima Y, Nakagawa F, Handa S, Oda T, Naito A, Yamazaki M
出版信息
FEBS Lett. 1985 Nov 18;192(2):179-83. doi: 10.1016/0014-5793(85)80103-4.
Griseolic acid inhibited cAMP phosphodiesterase (PDE) at low concentrations, the I50 being of the order of 0.01-0.1 microM. Administration of griseolic acid to rats increased the cAMP level in liver and plasma several-fold. It increased glycogen degradation in mouse liver and stimulated lipolysis in isolated rat fat cells. Griseolic acid did not block the adenosine-elicited accumulation of cAMP in guinea pig brain slices. It had no effect on cAMP-dependent protein kinase from rat liver nor on the adenyl cyclase from rat brain.
灰黄霉素酸在低浓度下可抑制环磷酸腺苷磷酸二酯酶（PDE），其半数抑制浓度（I50）约为0.01 - 0.1微摩尔。给大鼠施用灰黄霉素酸可使肝脏和血浆中的环磷酸腺苷水平提高数倍。它增加了小鼠肝脏中的糖原降解，并刺激了分离的大鼠脂肪细胞中的脂肪分解。灰黄霉素酸不会阻断豚鼠脑片中腺苷引发的环磷酸腺苷积累。它对大鼠肝脏中的环磷酸腺苷依赖性蛋白激酶以及大鼠脑中的腺苷酸环化酶均无影响。
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