Takahashi S, Nakagawa F, Kawazoe K, Furukawa Y, Sato S, Tamura C, Naito A
J Antibiot (Tokyo). 1985 Jul;38(7):830-4. doi: 10.7164/antibiotics.38.830.
Griseolic acid, a potent inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase, was isolated from the fermentation broth of Streptomyces griseoaurantiacus SANK 63479. Treatment of griseolic acid with HCl-MeOH gave adenine and pseudo-sugar. The structure of griseolic acid, adenine nucleoside type structure, was elucidated by chemical degradation and X-ray analysis, and was shown to be structure 1.
灰黄霉素酸是一种有效的环磷腺苷磷酸二酯酶抑制剂，它是从灰黄橙链霉菌SANK 63479的发酵液中分离得到的。用盐酸-甲醇处理灰黄霉素酸得到腺嘌呤和假糖。通过化学降解和X射线分析阐明了灰黄霉素酸的结构，即腺嘌呤核苷型结构，并显示为结构1。
