Aleknaviciute Jurate, Tulen Joke H M, de Rijke Yolanda B, van der Kroeg Mark, Kooiman Cornelis G, Kushner Steven A
Department of Psychiatry, Erasmus University Medical Center Rotterdam, The Netherlands.
Department of Clinical Chemistry, Erasmus University Medical Center Rotterdam, The Netherlands.
BJPsych Open. 2018 Jun 22;4(4):180-185. doi: 10.1192/bjo.2018.23. eCollection 2018 Jul.
The serotonin transporter gene-linked polymorphic region (5-HTTLPR) has previously been associated with hypothalamus-pituitary-adrenal axis function. Moreover, it has been suggested that this association is moderated by an interaction with stressful life experiences.
To investigate the moderation of cortisol response to psychosocial stress by 5-HTTLPR genotype, either directly or through an interaction with early life stress.
A total of 151 women, 85 of which had personality psychopathology, performed the Trier Social Stress Test while cortisol responsivity was assessed.
The results demonstrate a main effect of genotype on cortisol responsivity. Women carrying two copies of the long version of 5-HTTLPR exhibited stronger cortisol responses to psychosocial stress than women with at least one copy of the short allele ( = 0.03). However, the proportion of the variance of stress-induced cortisol responsivity explained by 5-HTTLPR genotype was not further strengthened by including early life adversity as a moderating factor ( = 0.52).
Our results highlight the need to clarify gender-specific biological factors influencing the serotonergic system. Furthermore, our results suggest that childhood maltreatment, specifically during the first 15 years of life, is unlikely to exert a moderating influence of large effect on the relationship between the 5-HTTLPR genotype and cortisol responsivity to psychosocial stress.
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血清素转运体基因连锁多态性区域（5-HTTLPR）先前已被证明与下丘脑-垂体-肾上腺轴功能有关。此外，有人提出这种关联会受到与应激性生活经历相互作用的调节。
研究5-HTTLPR基因型对心理社会应激时皮质醇反应的调节作用，无论是直接调节还是通过与早期生活应激的相互作用进行调节。
共有151名女性参与研究，其中85人患有个性心理病理学问题，她们进行了特里尔社会应激测试，同时评估了皮质醇反应性。
结果表明基因型对皮质醇反应性有主要影响。携带两份5-HTTLPR长版本拷贝的女性比至少携带一份短等位基因拷贝的女性对应激性生活事件表现出更强的皮质醇反应（P = 0.03）。然而，将早期生活逆境作为调节因素纳入后，5-HTTLPR基因型所解释的应激诱导皮质醇反应性变异比例并未进一步增加（P = 0.52）。
我们的结果凸显了明确影响血清素能系统的性别特异性生物学因素的必要性。此外，我们的结果表明，童年期虐待，尤其是在生命的前15年，不太可能对5-HTTLPR基因型与心理社会应激时皮质醇反应性之间的关系产生显著的调节作用。
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