Faculty of Natural & Environmental Sciences, University of Southampton, Highfield Campus, Southampton, SO17 1BJ, UK.
Department of Industrial Chemistry "Toso Montanari", University of Bologna, Viale Risorgimento 4, 40136, Bologna, Italy.
Chemistry. 2018 Sep 6;24(50):13306-13310. doi: 10.1002/chem.201802303. Epub 2018 Aug 10.
A novel catalytic enantioselective methodology based on synergistic catalysis for the synthesis of chiral 2-acyl pyridines and pyrazines is reported. The strategy involves the metal-Lewis acid activation of acetyl aza-arenes and the secondary-amine activation of enals. The proposed mechanism is supported by DFT calculations.
本文报道了一种基于协同催化的新型手性催化对映选择性方法，用于合成手性 2-酰基吡啶和吡嗪。该策略涉及乙酰氮杂芳烃的金属-路易斯酸活化和烯醛的仲胺活化。所提出的机制得到了 DFT 计算的支持。
