Department of Adults' Infectious Diseases, Medical University of Warsaw, Warsaw, Poland.
Hospital for Infectious Diseases, HIV Out-Patient Clinic, Warsaw, Poland.
HIV Med. 2018 Oct;19(9):629-633. doi: 10.1111/hiv.12641. Epub 2018 Jul 10.
Pre-exposure prophylaxis (PrEP) for HIV infection has been introduced in only a few European countries. We investigated the potential to provide PrEP in the Central and Eastern European region, and in neighbouring countries.
The Euroguidelines in Central and Eastern Europe (ECEE) Network Group was formed in February 2016 to review standards of care for HIV infection in the region. Information related to PrEP was collected through on-line surveys. Respondents were recruited by ECEE members based on their involvement in HIV care.
Seventy-six respondents from 23 countries participated in the survey. Twenty-six (34.2%) respondents reported that PrEP [tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)] was registered by the drug registration authority in their country. Fifty-three (70.7%) respondents reported being aware of 'informal' PrEP use in their country. If they had access to PrEP, 56 (74.7%) would advise its use in their practice. Forty-five (59.2%) respondents had concerns regarding PrEP use, and 10 (13.3%) expressed the need for more training. Most of the respondents (88.2%) would provide PrEP to people with high-risk behaviours.
PrEP is already used informally in some countries in the region. Physicians are keen to use PrEP if and when it is accessible. Obstacles towards implementing PrEP in those countries were mostly related to lack of national guidelines, drug registration and governmental strategy.
艾滋病毒感染的暴露前预防(PrEP)仅在少数欧洲国家推出。我们调查了在中东欧地区和邻国提供 PrEP 的潜力。
2016 年 2 月成立了中东欧欧指导方针(ECEE)网络小组,以审查该地区艾滋病毒感染的护理标准。通过在线调查收集了与 PrEP 相关的信息。根据他们参与艾滋病毒护理的情况,ECEE 成员招募了受访者。
来自 23 个国家的 76 名受访者参加了调查。26 名(34.2%)受访者报告称,其国家的药物注册管理机构已注册 PrEP[富马酸替诺福韦二吡呋酯(TDF)/恩曲他滨(FTC)]。53 名(70.7%)受访者报告称,他们的国家存在“非正式”PrEP 应用。如果他们能够获得 PrEP,56 名(74.7%)受访者将在他们的实践中建议使用 PrEP。45 名(59.2%)受访者对 PrEP 的使用表示担忧,10 名(13.3%)表示需要更多的培训。大多数受访者(88.2%)将为有高风险行为的人提供 PrEP。
该地区的一些国家已经在非正式地使用 PrEP。如果 PrEP 可用,医生们很愿意使用它。在这些国家实施 PrEP 的障碍主要与缺乏国家指南、药物注册和政府战略有关。