Hamerlynck J V, Maskens A P, Mangioni C, van der Burg M E, Wils J A, Vermorken J B, Rotmensz N
Gynecol Oncol. 1985 Nov;22(3):313-6. doi: 10.1016/0090-8258(85)90045-9.
Progestin therapy of ovarian carcinoma in the past has been reported to lead to varying response rates. A multicenter phase II study of high-dose MPA was conducted in 53 patients with epithelial ovarian cancer who had received adequate trials of conventional therapy with cytotoxic agents. Forty-one patients were included for response and toxicity evaluations. Only one partial response has been recorded with a duration of 20 weeks. Stabilization of disease was observed in 7 patients. The present investigation shows that MPA given at the present high dose is not effective in patients extensively pretreated with chemotherapy.
过去有报道称，孕激素疗法治疗卵巢癌的有效率各不相同。对53例上皮性卵巢癌患者进行了一项高剂量甲羟孕酮的多中心II期研究，这些患者均接受过足够疗程的细胞毒性药物常规治疗。41例患者纳入疗效和毒性评估。仅记录到1例部分缓解，持续时间为20周。7例患者病情稳定。目前的研究表明，对于接受过广泛化疗的患者，给予当前高剂量的甲羟孕酮无效。
