卵巢癌的周期性激素治疗。一项II期试验。
Cyclic hormonal treatment in ovarian cancer. A phase-II trial.
作者信息
Jakobsen A, Bertelsen K, Sell A
机构信息
Institute of Cancer Research, Danish Cancer Society, Aarhus, Denmark.
出版信息
Eur J Cancer Clin Oncol. 1987 Jul;23(7):915-6. doi: 10.1016/0277-5379(87)90335-x.
PMID:2959486
Abstract
Twenty-nine patients with advanced epithelial ovarian cancer were included in a phase-II trial of cyclic hormonal treatment. The schedule consisted of tamoxifen 10 mg X 3 daily for 14 days followed by medroxyprogesterone acetate 400 mg X 2 daily for 14 days. No objective response was recorded in 17 evaluable patients and cyclic hormonal treatment appears to be ineffective in advanced ovarian cancer.
摘要
29例晚期上皮性卵巢癌患者被纳入一项周期性激素治疗的II期试验。治疗方案为他莫昔芬10毫克，每日3次，共14天，随后醋酸甲羟孕酮400毫克，每日2次，共14天。17例可评估患者未记录到客观缓解，周期性激素治疗在晚期卵巢癌中似乎无效。
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