Bajunirwe Francis, Stothers Lynn, Berkowitz Jonathan, Macnab Andrew J
Department of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda.
Department of Urologic Sciences, and Associate Member School of Population and Public Health Division of Global Health, University of British Columbia, Vancouver, BC, Canada, and Principal Investigator, International Collaboration on Repair Discoveries (ICORD).
Can Urol Assoc J. 2018 Nov;12(11):E447-E452. doi: 10.5489/cuaj.5105. Epub 2018 Jun 8.
In the absence of specific regional data, the prevalence of urinary symptoms in the developing world is currently estimated. Regional prevalence data and estimates based on them have relevance for accurate planning/provision of future healthcare. We sought to extrapolate prevalence estimates for lower urinary tract symptom (LUTS) severity and associated sexual dysfunction for Uganda as a whole and sub-Saharan Africa (SSA) using newly available regional data from a community-based cohort of men in Uganda.
Global Burden of Disease Study (GBDS) population statistics were applied to a regional dataset to provide prevalence estimates for Uganda and SSA; 415 men >55 years from five rural Ugandan communities had completed the International Prostate Symptom Scale (IPSS) and Epstein inventory to grade their LUTS severity and satisfaction with sexual function.
Prevalence rates for moderate and severe LUTS were 40.5% and 20%, respectively, in men >55 in the Ugandan regional data; associated scores for all four Epstein sexual satisfaction measures were low. GBDS population figures (2016) for men >55 years are 942 115 (Uganda) and 33.9 million (SSA); hence, scaling up from regional prevalence data suggests 381 557 and 188 423 men >55 years in Uganda, and 13 729 500 and 6 780 000 in SSA have moderate and severe LUTS, respectively, and the majority will have compromise of elements of their sexual function.
Extrapolation from a small regional dataset (for which we have no guarantee of national or SSA representability) provides the first prevalence estimates for LUTS severity based on African data, and suggests a large proportion of men >55 years are troubled with LUTS and associated sexual dysfunction.
在缺乏特定区域数据的情况下，目前对发展中世界泌尿系统症状的患病率进行了估算。区域患病率数据以及基于这些数据的估算对于准确规划/提供未来的医疗保健具有重要意义。我们试图利用乌干达一个基于社区的男性队列的最新区域数据，推断出整个乌干达以及撒哈拉以南非洲（SSA）下尿路症状（LUTS）严重程度及相关性功能障碍的患病率估算值。
将全球疾病负担研究（GBDS）的人口统计数据应用于一个区域数据集，以提供乌干达和SSA的患病率估算值；来自乌干达五个农村社区的415名55岁以上男性完成了国际前列腺症状评分量表（IPSS）和爱泼斯坦量表，以评定他们的LUTS严重程度和性功能满意度。
在乌干达区域数据中，55岁以上男性中，中度和重度LUTS的患病率分别为40.5%和20%；爱泼斯坦所有四项性功能满意度指标的相关得分都很低。2016年GBDS中55岁以上男性的人口数据为乌干达942115人、SSA为3390万人；因此，根据区域患病率数据推算，乌干达55岁以上有中度和重度LUTS的男性分别为381557人和188423人，SSA分别为13729500人和6780000人，并且大多数人的性功能会受到影响。
从小规模区域数据集进行推断（我们无法保证其具有全国或SSA代表性）得出了基于非洲数据的LUTS严重程度的首批患病率估算值，并表明很大一部分55岁以上男性受LUTS及相关性功能障碍困扰。
