IEEE Trans Biomed Eng. 2018 Aug;65(8):1705-1710. doi: 10.1109/TBME.2017.2767828. Epub 2017 Oct 30.
we have developed a handheld device for noninvasive quantitative assessment of jugular venous pressure (JVP).
we used a single crystal ultrasound coupled to a force-sensing load cell to measure JVP based on the force necessary to collapse the internal jugular vein (IJV) walls. We used a gelatin-based model system of the IJV to test the ability of single crystal ultrasound to identify the IJV and verified the cross-sectional position and diameter of the vessels with conventional imaging ultrasound. We also tested our prototype device on healthy human volunteers.
experiments on model system demonstrated that vessel diameters determined with single crystal ultrasound were in close agreement with the diameters derived from conventional 2-D ultrasound. Proof-of-concept human experiments demonstrate that single crystal ultrasound can detect the IJV in basal and collapsed states, as compared to gold-standard sonography (insert stats). Assessment of JVP in human volunteers was physiologically consistent with and sensitive to postural changes (supine JVP 6.6 ± 2.4 mmHg; standing JVP 4.2 ± 1.9 mmHg (p < 0.0001).
noninvasive assessment of JVP could prove valuable in informing rapid clinical decision-making across various pathologies and conditions leading to derangements in intravascular volume status.
我们开发了一种用于颈静脉压（JVP）无创定量评估的手持式设备。
我们使用单晶超声耦合力感测负载细胞，根据塌陷颈内静脉（IJV）壁所需的力来测量 JVP。我们使用基于明胶的 IJV 模型系统来测试单晶超声识别 IJV 的能力，并使用常规成像超声验证血管的横截面积和直径。我们还在健康志愿者身上测试了我们的原型设备。
模型系统上的实验表明，单晶超声确定的血管直径与常规 2-D 超声得出的直径非常吻合。人体初步实验证明，与金标准超声相比，单晶超声可以检测到基础和塌陷状态下的 IJV（插入统计数据）。对志愿者 JVP 的评估在生理学上与体位变化一致，并且对体位变化敏感（仰卧 JVP 为 6.6±2.4mmHg；站立 JVP 为 4.2±1.9mmHg（p<0.0001）。
JVP 的无创评估可能在各种导致血管内容量状态紊乱的病理和病症中为快速临床决策提供有价值的信息。
