Zajtchuk R, Collins G J, Holley P W, Heydron W H, Schuchmann G F, Hamaker W R
J Thorac Cardiovasc Surg. 1977 Feb;73(2):309-11.
Thirty patients in whom all aorta-coronary artery vein grafts became occluded within one year of operation, as demonstrated by cardiac catheterization, were evaluated for hypercoagulability. A total of 59 grafts were constructed in these patients. At operation, blood flows of 35 to 90 c.c. per minute were measured through the grafts. In 23 of the 30 patients, the blood was to be hypercoagulable, as evidenced by a low level of antithrombin III activity, high thrombin generation index, high factor VII values, or high platelet adhesivity. Another group of 11 patients (total number of grafts, 23) had all grafts patent at cardiac catheterization. These patients had flows through the grafts ranging from 20 to 125 c.c. per minute. None of the patients with patent grafts had hypercoagulable blood. The status of runoff was comparable between the patients with open grafts and those with occluded grafts.
通过心导管检查证实，30例患者的所有主动脉-冠状动脉静脉移植物在术后1年内均发生闭塞，对这些患者进行了高凝状态评估。这些患者共构建了59个移植物。手术时，通过移植物测得的血流量为每分钟35至90立方厘米。30例患者中有23例血液呈高凝状态，表现为抗凝血酶III活性水平低、凝血酶生成指数高、因子VII值高或血小板黏附性高。另一组11例患者（移植物总数为23个）在心导管检查时所有移植物均通畅。这些患者的移植物血流量为每分钟20至125立方厘米。移植物通畅的患者中无一例血液呈高凝状态。移植物通畅的患者与移植物闭塞的患者之间的血流情况相当。
