乌克兰人群中药物遗传学重要多态性的分布。
Distribution of pharmacogenetically important polymorphism in the Ukrainian population.
作者信息
Filiptsova Olga, Kobets Marina, Kobets Julia, Naboka Olga, Koiro Olga, Ochkur Alexandr, Galiy Larisa
机构信息
Biology Department, National University of Pharmacy, Pushkinska Street, 53, Kharkov 61002, Ukraine.
Pharmaceutical Marketing and Management Department, National University of Pharmacy, Pushkinska Street, 53, Kharkov 61002, Ukraine.
出版信息
Saudi Pharm J. 2018 Jul;26(5):651-655. doi: 10.1016/j.jsps.2018.02.027. Epub 2018 Feb 15.
The CYP2B6 is one of the members of the cytochrome P450 superfamily. This enzyme metabolizes a number of currently prescribed drugs and different compounds. In light of clinical significance of the variant of the gene, the aim of this study was to investigate the distribution of one of the gene polymorphisms, namely, the in the Ukrainian population. The study cohort consisted of 102 healthy Ukrainian adults (48 males, 54 females). Genotyping of the (rs3745274) polymorphism in the study subjects was carried out using a polymerase chain reaction. The following distribution of genotypes in the Ukrainian cohort was identified: - in 56%, - in 37% and - in 7%. The allele frequency of the gene in population was = 0.75 and = 0.25, respectively. The population-based sequences were analyzed by the Hardy-Weinberg method. The genetic polymorphism revealed in the Ukrainian population suggests the polymorphism of the genetic testing when prescribing the drugs that are substrates of this gene.
细胞色素P450 2B6（CYP2B6）是细胞色素P450超家族的成员之一。该酶可代谢多种当前正在使用的处方药和不同化合物。鉴于该基因变异的临床意义，本研究旨在调查乌克兰人群中该基因的一种多态性，即CYP2B6基因rs3745274多态性的分布情况。研究队列由102名健康的乌克兰成年人组成（48名男性，54名女性）。采用聚合酶链反应对研究对象的CYP2B6基因rs3745274多态性进行基因分型。在乌克兰队列中确定了以下CYP2B6基因型分布：CC型占56%，CT型占37%，TT型占7%。该基因在人群中的C和T等位基因频率分别为p = 0.75和q = 0.25。采用哈迪-温伯格方法对基于人群的序列进行分析。乌克兰人群中发现的基因多态性表明，在开具该基因底物药物时，对CYP2B6基因进行基因检测具有多态性。
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