Basturk Ahmet, Artan Reha, Yılmaz Aygen, Gelen Mustafa T
Department of Pediatric Gastroenterology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Department of Pathology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Pediatr Gastroenterol Hepatol Nutr. 2018 Jul;21(3):163-169. doi: 10.5223/pghn.2018.21.3.163. Epub 2018 Jun 28.
The aim of this study is to determine the involvement of the upper gastrointestinal system (GIS) in patients diagnosed with Crohn's disease (CD), ulcerative colitis (UC), and non-inflammatory bowel disease (IBD) and to compare their differences.
This study included patients aged between 2 and 18 years who underwent colonoscopy and esophagogastroduodenoscopy (EGD) for the first time due to the prediagnosis of IBD. In EGD, samples were taken from duodenum, antrum, corpus, and esophagus; and gastritis, duodenitis, and esophagitis were identified through histopathologic examination. The data gathered the ends of the research were compared between IBD with non-IBD groups and between CD-UC with non-IBD groups, and the presence of significant differences between groups were determined.
In our study, 16 patients were diagnosed with CD, 13 with UC, 3 with undeterminate colitis, and 13 with non-IBD. In the histopathological examination of the groups, GIS involvement was found in 94.1% of patients diagnosed with IBD and in 38.5% of non-IBD patients. Moreover, the difference was found to be statistically significant (=0.032). No significant difference was found between the CD and UC groups. Gastritis was mostly observed in 93.8% of CD-diagnosed patients, 76.8% of UC-diagnosed patients, 81.2% of IBD-diagnosed patients, and 38.5% of non-IBD-diagnosed patients. On the other hand, significant differences were found between CD and non-IBD groups (=0.03), UC and non-IBD groups (=0.047), and IBD and non-IBD groups (=0.03).
The results of the study show that gastritis was highly observed in UC- and CD-diagnosed patients than in non-IBD-diagnosed patients.
本研究旨在确定诊断为克罗恩病（CD）、溃疡性结肠炎（UC）和非炎症性肠病（IBD）的患者上消化道系统（GIS）的受累情况，并比较它们之间的差异。
本研究纳入了2至18岁因IBD预诊断而首次接受结肠镜检查和食管胃十二指肠镜检查（EGD）的患者。在EGD中，从十二指肠、胃窦、胃体和食管采集样本；通过组织病理学检查确定胃炎、十二指肠炎和食管炎。将研究结束时收集的数据在IBD组与非IBD组之间以及CD-UC组与非IBD组之间进行比较，并确定组间是否存在显著差异。
在我们的研究中，16例患者被诊断为CD，13例为UC，3例为未定型结肠炎，13例为非IBD。在各组的组织病理学检查中，94.1%诊断为IBD的患者和38.5%的非IBD患者存在GIS受累。此外，发现差异具有统计学意义（P=0.032）。CD组和UC组之间未发现显著差异。胃炎在93.8%诊断为CD的患者、76.8%诊断为UC的患者、81.2%诊断为IBD的患者和38.5%诊断为非IBD的患者中最为常见。另一方面，CD组与非IBD组之间（P=0.03）、UC组与非IBD组之间（P=0.047）以及IBD组与非IBD组之间（P=0.03）均发现有显著差异。
研究结果表明，诊断为UC和CD的患者比诊断为非IBD的患者胃炎发生率更高。
