Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Graduate Management Unit, Changhai Hospital, Second Military Medical University, Shanghai, China.
Biomed Res Int. 2018 May 27;2018:7625078. doi: 10.1155/2018/7625078. eCollection 2018.
To investigate trends in long-noncoding (lnc) RNA research systematically, we compared the contribution of publications among different regions, institutions, and authors. Publications on lncRNA were retrieved from Web of Science (WoS) from 1975 to 2017. A total of 3879 papers were identified, and together they were cited 62967 times. The literature on lncRNA had been continuously growing since 2006, and the expansion might continue at a rapid pace until around 2021. China contributed the greatest proportion (63.47%) of lncRNA publications, and the USA ranked second in the number of publications (944 articles), while it had the highest citation frequency (43168 times) and H-index (97). The journal has the greatest number of publications on lncRNA research, with 305 papers. The keywords could be stratified into two clusters: cluster 1 (application) and cluster 2 (characteristics). Correspondingly, the "TNM stage," "epithelial mesenchymal transition (EMT)," "cell apoptosis," and "overall survival" are research hotspots since 2015. Thus, research on lncRNA showed a swiftly expanding trend, with China making the largest contribution. The focus on lncRNA is gradually shifting from "characteristics" to "application."
为了系统地研究长链非编码（lnc）RNA 的研究趋势，我们比较了不同地区、机构和作者的出版物的贡献。从 1975 年到 2017 年，我们从 Web of Science（WoS）中检索了 lncRNA 的出版物。共确定了 3879 篇论文，它们共被引用了 62967 次。自 2006 年以来，lncRNA 的文献一直在持续增长，并且这种增长可能会以很快的速度持续到 2021 年左右。中国在 lncRNA 出版物中占比最大（63.47%），美国在出版物数量上排名第二（944 篇），但它的引用频率（43168 次）和 H 指数（97）最高。期刊在 lncRNA 研究方面发表的论文最多，有 305 篇。关键词可以分为两个聚类：聚类 1（应用）和聚类 2（特征）。相应地，自 2015 年以来，“TNM 分期”、“上皮间质转化（EMT）”、“细胞凋亡”和“总生存期”是研究热点。因此，lncRNA 的研究呈现出迅速扩张的趋势，中国的贡献最大。对 lncRNA 的关注正逐渐从“特征”转向“应用”。
