Intestinal Mucosal Biology Laboratory, School of Health Sciences, University of Tasmania, Tasmania, Australia.
Curr Pharm Des. 2018;24(27):3176-3183. doi: 10.2174/1381612824666180711122753.
Initiating anti-apoptotic signaling or triggering cell death depends to a great extent on the nature or source of cellular stress and cell type. Interplay between each stress response eventually determines the fate of stressed cell. Numerous factors induce cell death by a number of pathways including apoptosis, autophagy and necrosis. Not surprisingly, some of the pathways are interrelated to each other through a mediator that could articulate the entire mechanism. The present review attempts to consolidate all the pathways included in intrinsic cellular stress such as oxidative stress and autophagy, endoplasmic reticular stress (ERS) and mitophagy and apoptosis as fate in cell stress. These stress responses are a hallmark of numerous diseases including neurodegenerative diseases, diabetes and cancer. Understanding the cross-talk between different intrinsic cell stress responses will help to develop new therapeutic targets and hence lead to the development of new therapeutics.
细胞应激的命运取决于细胞应激的性质或来源以及细胞类型。每种应激反应之间的相互作用最终决定了应激细胞的命运。许多因素通过包括凋亡、自噬和坏死在内的多种途径诱导细胞死亡。毫不奇怪，一些途径通过一个可以阐明整个机制的介质相互关联。本综述试图整合包括氧化应激和自噬、内质网应激 (ERS) 和线粒体自噬以及细胞应激中的凋亡等内在细胞应激途径。这些应激反应是许多疾病的特征，包括神经退行性疾病、糖尿病和癌症。了解不同内在细胞应激反应之间的串扰将有助于开发新的治疗靶点，并因此导致新的治疗方法的发展。
