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被动吸入大麻烟雾后血液和尿液中的大麻素。

Cannabinoids in blood and urine after passive inhalation of Cannabis smoke.

作者信息

Mørland J, Bugge A, Skuterud B, Steen A, Wethe G H, Kjeldsen T

出版信息

J Forensic Sci. 1985 Oct;30(4):997-1002.

PMID:2999292
Abstract

To test the possibility that cannabinoids are detectable following passive inhalation of Cannabis smoke the following study was performed. Five healthy volunteers who had previously never used Cannabis, passively inhaled Cannabis smoke for 30 min. Cannabis smoke was provided by other subjects smoking either marijuana or hashish cigarettes in a small closed car, containing approximately 1650 L of air. delta 9-Tetrahydrocannabinol (THC) could be detected in the blood of all passive smokers immediately after exposure in concentrations ranging from 1.3 to 6.3 ng/mL. At the same time total blood cannabinoid levels (assayed by radioimmunoassay [RIA] ) were higher than 13 ng/mL in four of the volunteers. Both THC and cannabinoid blood concentrations fell close to the cutoff limits of the respective assays during the following 2 h. Passive inhalation also resulted in the detection of cannabinoids in the urine by RIA and enzyme multiple immunoassay technique (EMIT) assays (above 13 and 20 ng/mL, respectively). It is concluded that the demonstration of cannabinoids in blood or urine is no unequivocal proof of active Cannabis smoking.

摘要

为了测试被动吸入大麻烟雾后是否可检测到大麻素,进行了以下研究。五名此前从未使用过大麻的健康志愿者被动吸入大麻烟雾30分钟。大麻烟雾由其他受试者在一辆小型封闭汽车内吸食大麻或哈希什香烟产生,车内约有1650升空气。暴露后立即在所有被动吸烟者的血液中检测到Δ⁹-四氢大麻酚(THC),浓度范围为1.3至6.3纳克/毫升。同时,四名志愿者的总血大麻素水平(通过放射免疫分析[RIA]测定)高于13纳克/毫升。在接下来的2小时内,THC和血大麻素浓度均降至各自检测方法的临界值附近。被动吸入还导致通过RIA和酶多重免疫分析技术(EMIT)检测到尿液中的大麻素(分别高于13和20纳克/毫升)。结论是,血液或尿液中大麻素的检测并不能明确证明是主动吸食大麻。

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Cannabinoids in blood and urine after passive inhalation of Cannabis smoke.被动吸入大麻烟雾后血液和尿液中的大麻素。
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