Yonamine Mauricio, Garcia Paula Rodrigues, de Moraes Moreau Regina Lúcia
Laboratory of Analytical Toxicology, College of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, B13B, CEP: 05508-900, São Paulo, Brazil.
Sports Med. 2004;34(11):697-704. doi: 10.2165/00007256-200434110-00001.
Compulsory drug testing was introduced in 1968 by the International Olympic Committee. Since then, several doping cases have been reported in sports competition world wide. Positive results are based on the detection of prohibited substances, their metabolites and markers in biological (mainly urine) samples supplied by athletes. In some cases, the evidences were not contested and athletes admitted the use of banned substances. However, in other cases, athletes denied the use of doping to enhance performance and claimed to have inadvertently or passively absorbed the drug. Unfortunately, no current accepted analytical method is capable of distinguishing between a sample from a cheater and one from an athlete who was passively exposed to a doping agent. Athletes' allegations have included the passive inhalation of drug smoke (e.g. marijuana) or the ingestion of food or products sold as nutritional supplements that contained prohibited substances. In the scientific literature, several studies have been performed to investigate the possibility of an accidental exposure being the reason for the appearance of detectable quantities of banned substances in urine samples. Based on these studies, this article discusses those cases where the athlete's claims could be possible in generating a positive result in doping control and in which circumstances it would be improbable to happen.
1968年,国际奥委会引入了强制药物检测。从那时起,世界各地的体育比赛中就不断有兴奋剂事件被报道。检测呈阳性是基于在运动员提供的生物样本(主要是尿液)中检测到违禁物质、其代谢物和标记物。在某些情况下,证据无可争议,运动员承认使用了违禁物质。然而,在其他情况下,运动员否认使用兴奋剂来提高成绩,并声称是无意中或被动地摄入了药物。不幸的是,目前没有一种被认可的分析方法能够区分作弊者的样本和被动接触兴奋剂的运动员的样本。运动员的说法包括被动吸入药物烟雾(如大麻)或摄入含有违禁物质的作为营养补充剂出售的食品或产品。在科学文献中,已经进行了几项研究来调查意外接触是否可能是尿液样本中出现可检测量违禁物质的原因。基于这些研究,本文讨论了哪些情况下运动员的说法有可能导致兴奋剂检测呈阳性,以及在哪些情况下这种情况不太可能发生。