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[先天性唇腭裂患儿口腔治疗阶段的综合康复]

[Complex rehabilitation of children with congenital cleft lip and palate at stomatological treatment stages].

作者信息

Mitropanova M N

机构信息

Head of the Department of Pediatric Dentistry, Orthodontics and Maxillofacial Surgery, Kuban State Medical University of Ministry of Health Care, Russian Federation, Krasnodar, Russia.

出版信息

Stomatologiia (Mosk). 2018;97(3):48-53. doi: 10.17116/stomat201897348.

Abstract

Congenital malformations of the maxillofacial area - congenital cleft lip and palate (CCLP) due to their frequency, the severity of anatomical and functional disorders, the difficulty of social adaptation of patients, economic aspects are one of the most important problems of medicine. It is established that for timely stage surgical treatment of children with IAPC the emphasis is on the somatic status of the child, anti-infective resistance, the ability to safely tolerate surgery, which is important for the restoration of anatomical defects, communication functions and psychosomatic health. Children with CCLP are at risk for increased occurrence of postoperative complications, since upper respiratory tract infection and exacerbation of chronic respiratory tract diseases and ENT organs is a contraindication to surgical intervention. The study of immune status revealed deep violations of antiviral and antibacterial immunity in children with CCPC aged from 6 to 12 years. A program of combine interferon- and immunotherapy has been created. Positive clinical and immunological efficacy of combine interferon-(gel Viferon - recombinant IFNα2b in combination with antioxidant) and immunotherapy in the rehabilitation of children with CCPC aged 6 to 12 years was demonstrated.

摘要

颌面部先天性畸形——先天性唇腭裂(CCLP),鉴于其发病率、解剖和功能障碍的严重程度、患者社会适应的困难程度以及经济方面的因素,是医学领域最重要的问题之一。已经确定,对于IAPC患儿的及时手术治疗,重点在于患儿的身体状况、抗感染抵抗力、安全耐受手术的能力,这对于修复解剖缺陷、交流功能和身心健康非常重要。CCLP患儿术后并发症发生率增加,因为上呼吸道感染以及慢性呼吸道疾病和耳鼻喉器官的加重是手术干预的禁忌症。对免疫状态的研究揭示了6至12岁CCPC患儿抗病毒和抗菌免疫的严重缺陷。已经制定了联合干扰素和免疫治疗方案。证明了联合干扰素(凝胶维夫隆——重组IFNα2b与抗氧化剂联合)和免疫治疗在6至12岁CCPC患儿康复中的积极临床和免疫疗效。

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