[胃癌组织多肽抗原（TPA）的临床研究]
[Clinical study on tissue polypeptide antigen (TPA) in gastric cancer].
作者信息
Kanauchi M, Sawai F, Hirayama T, Yumura F, Kanauchi K, Hamaguchi T, Hara Y, Yoshimura K, Nishiura K, Dohi K
出版信息
Gan No Rinsho. 1985 Sep;31(11):1367-71.
We evaluated whether assay of tissue polypeptide antigen (TPA) in the serum ia valuable for the determination of cancer stages compared to other tumor markers such as CEA, AFP, and ferritin. The study population consisted of 79 gastric cancer patients and 212 patients with benign gastroenteric disease. The percentage of positive cases for TPA (higher than 200u/l) was 41% in gastric cancer and 20% in active peptic ulcer. Serum TPA levels in well differentiated carcinoma and signet ring cell carcinoma were higher than that in other histological types. Serum TPA levels correlated well with the stage of the gastric cancer.
我们评估了与癌胚抗原（CEA）、甲胎蛋白（AFP）和铁蛋白等其他肿瘤标志物相比，血清组织多肽抗原（TPA）检测对于癌症分期测定是否有价值。研究对象包括79例胃癌患者和212例良性胃肠疾病患者。TPA阳性病例（高于200u/l）的百分比在胃癌患者中为41%，在活动性消化性溃疡患者中为20%。高分化癌和印戒细胞癌患者的血清TPA水平高于其他组织学类型患者。血清TPA水平与胃癌分期密切相关。
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