Thomas E, Enders-Ruckle G, Geursen R G
Klin Padiatr. 1985 Sep-Oct;197(5):415-8. doi: 10.1055/s-2008-1034013.
Chickenpox, which normally is an innocuous disease in children, may cause serious sequelae in immunocompromised hosts. An open prospective study is presented, that comprised 96 of such patients. They were treated with 0,2 ml/kg Varicella-Zoster-Immunoglobulin (VZIG) prophylactically or after exposure. The immunoglobulin was given in between 72 hours after known contact, newborns received the injection at the day of delivery. After that the patients were followed for six weeks for documentation and assessment of protection. In 85 (88,5%) cases there was no manifestation of varicella. 10 patients showed mild forms of the disease; 3 of these had got the preparation within the recommended time gap of 72 hours after exposure. One child died from varicella pneumonia and haemorrhage. In this case the preparation had only been given 10 days after contact.
水痘通常在儿童中是一种无害的疾病，但在免疫功能低下的宿主中可能会导致严重的后遗症。本文介绍了一项开放性前瞻性研究，该研究纳入了96例此类患者。他们在接触水痘带状疱疹免疫球蛋白（VZIG）后接受了0.2ml/kg的预防性治疗。已知接触水痘后72小时内给予免疫球蛋白，新生儿在分娩当天接受注射。之后，对患者进行了六周的随访，以记录和评估保护情况。85例（88.5%）患者未出现水痘症状。10例患者表现为轻症水痘；其中3例在接触后72小时的推荐时间间隔内接受了治疗。一名儿童死于水痘肺炎和出血。在这种情况下，接触后10天才给予治疗。
