位阻保护的四唑用于荧光光点击反应：调控环加成反应速率和产物荧光。
Sterically shielded tetrazoles for a fluorogenic photoclick reaction: tuning cycloaddition rate and product fluorescence.
机构信息
Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260, USA.
出版信息
Org Biomol Chem. 2018 Jul 25;16(29):5241-5244. doi: 10.1039/c8ob01404c.
Abstract
A panel of sterically shielded tetrazoles with different N-aryl groups were synthesized and subsequently evaluated in the photoinduced tetrazole-alkene cycloaddition reaction. It was found that increase in the HOMO energy of the corresponding nitrile imines leads to a faster cycloaddition reaction along with a red shift in the fluorescence emission of the pyrazoline cycloadduct.
摘要
一组具有不同 N-芳基的位阻保护的四唑被合成，并随后在光诱导的四唑-烯烃环加成反应中进行了评估。研究发现，相应的腈亚胺的 HOMO 能增加会导致更快的环加成反应，同时吡唑啉环加成产物的荧光发射发生红移。
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