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ProTide 生成长效阿巴卡韦纳米制剂。

ProTide generated long-acting abacavir nanoformulations.

机构信息

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA.

出版信息

Chem Commun (Camb). 2018 Jul 24;54(60):8371-8374. doi: 10.1039/c8cc04708a.

DOI:10.1039/c8cc04708a
PMID:29995046
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6063073/
Abstract

Abacavir pronucleotide nanoformulations (NM3ABC) were prepared as a novel long acting slow effective release antiretroviral therapy. Single NM3ABC treatment of human monocyte-derived macrophages produced sustained intracellular carbovir-triphosphate and antiretroviral activities for up to 30 days.

摘要

阿巴卡韦前药纳米制剂（NM3ABC）被制备为一种新型长效缓慢有效的抗逆转录病毒疗法。单次 NM3ABC 处理人单核细胞衍生的巨噬细胞可产生持续的细胞内卡波韦三磷酸和抗逆转录病毒活性，长达 30 天。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3aff/6063073/96a4a1d4510c/c8cc04708a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3aff/6063073/1f2875a21696/c8cc04708a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3aff/6063073/2af602862131/c8cc04708a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3aff/6063073/67661a0e4106/c8cc04708a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3aff/6063073/96a4a1d4510c/c8cc04708a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3aff/6063073/1f2875a21696/c8cc04708a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3aff/6063073/2af602862131/c8cc04708a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3aff/6063073/67661a0e4106/c8cc04708a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3aff/6063073/96a4a1d4510c/c8cc04708a-f3.jpg

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Long-acting approaches for delivery of antiretroviral drugs for prevention and treatment of HIV: a review of recent research.长效抗逆转录病毒药物递送方法用于预防和治疗 HIV：近期研究综述。
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Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues.棒状治疗性纳米粒子促进了抗逆转录病毒药物在人类免疫缺陷病毒易感细胞和组织中的分布和活性。
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Synthesis and Characterization of Long-Acting Darunavir Prodrugs.合成与长效达芦那韦前药的表征。
Mol Pharm. 2020 Jan 6;17(1):155-166. doi: 10.1021/acs.molpharmaceut.9b00871. Epub 2019 Dec 3.
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A long acting nanoformulated lamivudine ProTide.长效纳米制剂拉米夫定 ProTide
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