ProTide 生成长效阿巴卡韦纳米制剂。
ProTide generated long-acting abacavir nanoformulations.
机构信息
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA.
出版信息
Chem Commun (Camb). 2018 Jul 24;54(60):8371-8374. doi: 10.1039/c8cc04708a.
Abstract
Abacavir pronucleotide nanoformulations (NM3ABC) were prepared as a novel long acting slow effective release antiretroviral therapy. Single NM3ABC treatment of human monocyte-derived macrophages produced sustained intracellular carbovir-triphosphate and antiretroviral activities for up to 30 days.
摘要
阿巴卡韦前药纳米制剂（NM3ABC）被制备为一种新型长效缓慢有效的抗逆转录病毒疗法。单次 NM3ABC 处理人单核细胞衍生的巨噬细胞可产生持续的细胞内卡波韦三磷酸和抗逆转录病毒活性，长达 30 天。
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