Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, Cornell University, 413 East 69th Street, Box 290, New York, NY 10021, USA.
Chem Commun (Camb). 2018 Jul 24;54(60):8367-8370. doi: 10.1039/c8cc01795f.
Inspired by cisplatin's deactivation by glutathione (GSH) in cancer, a GSH responsive nanogel loaded with doxorubicin (Dox) was prepared using hyaluronan as a matrix and cisplatin as a crosslinker. The elevated GSH depletes the cisplatin crosslinker in the nanogel, enhances Dox release and boosts cytotoxicity, thus providing a new GSH responsive platform to reverse cisplatin resistance.
受顺铂在癌症中被谷胱甘肽 (GSH) 失活的启发，本文使用透明质酸作为基质，顺铂作为交联剂，制备了一种载有阿霉素 (Dox) 的 GSH 响应性纳米凝胶。升高的 GSH 会耗尽纳米凝胶中的顺铂交联剂，增强 Dox 的释放并提高细胞毒性，从而为逆转顺铂耐药提供了一个新的 GSH 响应平台。
