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支气管镜局部类固醇喷雾预防支气管结核所致瘢痕性支气管狭窄:病例系列

Bronchoscopic local steroid spray to prevent bronchial tuberculosis-induced cicatricial bronchial stenosis: A case series.

作者信息

Yaguchi Daizo, Ichikawa Motoshi, Shizu Masato, Inoue Noriko, Kobayashi Daisuke, Imai Naoyuki

机构信息

Deparment of Repiratory Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan.

出版信息

Medicine (Baltimore). 2018 Jul;97(28):e11464. doi: 10.1097/MD.0000000000011464.

Abstract

RATONALE

Cicatricial bronchial stenosis or obstruction occurring in the healing process of endobronchial tuberculosis (ET) is a problematic complication of tuberculous airway lesions. Prevention by internal medical treatment is desired.

PATIENT CONCERNS

This case series describes four patients who diagnosed ET with Type IIIb (protruding ulcer-type) based on Arai's classification of bronchoscopic findings of bronchial tuberculosis.

DIAGNOSES

Endobronchial tuberculosis.

INTERVENTIONS

A local steroid spray was applied bronchoscopically to active protruding ulcer-type lesions (which are likely to cause cicatricial stenosis) that extended in the transverse direction and occupied one-half or more of the circumference on bronchoscopy.

OUTCOMES

Cicatricial stenosis was prevented in two of four patients. Treatment was discontinued in athird patient because tolerance could not be achieved, although the patient's condition had improved. In the fourth patient, treatment was switched to systemic steroid administration because of a problem with tolerance and the broad range of the lesion; however, stenosis remained.

LESSONS

Local steroid spray-applied bronchoscopically to bronchial tuberculosis lesions in the ulcer formation and granulation periods may help prevent stenosis.

摘要

原理

支气管内膜结核(ET)愈合过程中发生的瘢痕性支气管狭窄或阻塞是结核性气道病变的一个棘手并发症。期望通过内科治疗进行预防。

患者情况

本病例系列描述了4例根据荒井对支气管结核支气管镜检查结果的分类诊断为Ⅲb型(突出溃疡型)ET的患者。

诊断

支气管内膜结核。

干预措施

通过支气管镜对在支气管镜检查中横向延伸且占据圆周一半或更多的活动性突出溃疡型病变(可能导致瘢痕性狭窄)进行局部类固醇喷雾治疗。

结果

4例患者中有2例预防了瘢痕性狭窄。第3例患者尽管病情有所改善,但因无法耐受而停止治疗。第4例患者因耐受性问题和病变范围广泛而改为全身类固醇给药;然而,仍出现了狭窄。

经验教训

在溃疡形成期和肉芽形成期对支气管结核病变进行支气管镜下局部类固醇喷雾治疗可能有助于预防狭窄。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e721/6076191/f69f5107e806/medi-97-e11464-g002.jpg

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