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细胞周期蛋白 G 与多梳抑制复合物 PRC1 和 PR-DUB 共同维持发育稳定性。

Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability.

机构信息

Sorbonne Université, Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Paris-Seine (IBPS), Laboratory of Developmental Biology (LBD), Paris, France.

Institut de biologie de l'Ecole normale supérieure (IBENS), Ecole normale supérieure, CNRS, INSERM, PSL Université Paris Paris, France.

出版信息

PLoS Genet. 2018 Jul 11;14(7):e1007498. doi: 10.1371/journal.pgen.1007498. eCollection 2018 Jul.

DOI:10.1371/journal.pgen.1007498
PMID:29995890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6065198/
Abstract

In Drosophila, ubiquitous expression of a short Cyclin G isoform generates extreme developmental noise estimated by fluctuating asymmetry (FA), providing a model to tackle developmental stability. This transcriptional cyclin interacts with chromatin regulators of the Enhancer of Trithorax and Polycomb (ETP) and Polycomb families. This led us to investigate the importance of these interactions in developmental stability. Deregulation of Cyclin G highlights an organ intrinsic control of developmental noise, linked to the ETP-interacting domain, and enhanced by mutations in genes encoding members of the Polycomb Repressive complexes PRC1 and PR-DUB. Deep-sequencing of wing imaginal discs deregulating CycG reveals that high developmental noise correlates with up-regulation of genes involved in translation and down-regulation of genes involved in energy production. Most Cyclin G direct transcriptional targets are also direct targets of PRC1 and RNAPolII in the developing wing. Altogether, our results suggest that Cyclin G, PRC1 and PR-DUB cooperate for developmental stability.

摘要

在果蝇中，广泛表达的短 Cyclin G 异构体通过波动不对称性（FA）产生极端的发育噪声，为解决发育稳定性问题提供了一个模型。这种转录性 Cyclin 与 Enhancer of Trithorax 和 Polycomb（ETP）和 Polycomb 家族的染色质调节剂相互作用。这促使我们研究这些相互作用在发育稳定性中的重要性。Cyclin G 的失调突出了与 ETP 相互作用结构域相关的器官内在发育噪声控制，并受编码 Polycomb 抑制复合物 PRC1 和 PR-DUB 成员的基因突变增强。对 CycG 失调的翅 imaginal 盘进行深度测序表明，高发育噪声与参与翻译的基因上调和参与能量产生的基因下调相关。大多数 Cyclin G 的直接转录靶标也是发育中翅膀中 PRC1 和 RNAPolII 的直接靶标。总之，我们的结果表明，Cyclin G、PRC1 和 PR-DUB 为发育稳定性而合作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/effba4888129/pgen.1007498.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/4bc4106bf7a8/pgen.1007498.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/ea1da56b5b19/pgen.1007498.g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/3f6d3b55991d/pgen.1007498.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/d3841963d73f/pgen.1007498.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/7d5620033a0e/pgen.1007498.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/64a71f800c0b/pgen.1007498.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/effba4888129/pgen.1007498.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/4bc4106bf7a8/pgen.1007498.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/ea1da56b5b19/pgen.1007498.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/5c269bfd9992/pgen.1007498.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/a7a243e5cb28/pgen.1007498.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/1cab6f8632c8/pgen.1007498.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/3f6d3b55991d/pgen.1007498.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/d3841963d73f/pgen.1007498.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/7d5620033a0e/pgen.1007498.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/64a71f800c0b/pgen.1007498.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79d/6065198/effba4888129/pgen.1007498.g010.jpg

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