Wang Anqi, Chen Shun, Wang Mingshu, Cheng Anchun
Bing Du Xue Bao. 2016 Jul;32(4):509-15.
Interferon inducible transmembrane proteins(IFITMs)are restriction factors with broad-spectrum antiviral functions in infected cells. IFITM genes belong to a large subfamily of dispanins and have multiple functions, amongst which the antiviral functions are the main focus of study. IFITMs, especially IFITM3,can restrict the early replication of viruses such as avian influence virus, and, therefore, have become a hot topic in research in recent years. To date, studies have shown that IFITMs restrict virus invasion mainly through endosomal pathways, subsequently inhibiting viral replication. However, a detailed antiviral mechanism is still unclear. Here, we summarize the advances in IFITM research from recent years.
干扰素诱导跨膜蛋白（IFITMs）是感染细胞中具有广谱抗病毒功能的限制因子。IFITM基因属于一个庞大的分散蛋白亚家族，具有多种功能，其中抗病毒功能是主要研究重点。IFITMs，尤其是IFITM3，能够限制禽流感病毒等病毒的早期复制，因此近年来已成为研究热点。迄今为止，研究表明IFITMs主要通过内体途径限制病毒入侵，随后抑制病毒复制。然而，具体的抗病毒机制仍不清楚。在此，我们总结近年来IFITM研究的进展。
