Zeng Miao, Chen Shun, Wang Mingshu, Chen Anchun
Bing Du Xue Bao. 2016 Sep;32(5):627-33.
As direct antiviral effector proteins, the innate antiviral proteins induced by pathogens and interferon can restrict intracellular viral infection at an early stage, establishing the state of the host antiviral immune response. Mx, PKR, OAS, IFITM, ZAP, and other proteins have all been shown to play important roles in the antiviral response. The host innate immune factors Mx and IFITM are both key antiviral effectors against influenza, while the antiviral mechanism of viperin remains to be completely elucidated. Research on the avian innate immune system is still at an early stage, resulting in fragmented knowledge in this area. Moreover, mechanisms of intrinsic and innate immunity in birds remain unclear.
作为直接抗病毒效应蛋白，病原体和干扰素诱导的先天性抗病毒蛋白可在早期限制细胞内病毒感染，从而建立宿主抗病毒免疫反应状态。Mx、PKR、OAS、IFITM、ZAP等蛋白均已被证明在抗病毒反应中发挥重要作用。宿主先天性免疫因子Mx和IFITM都是抗流感的关键抗病毒效应器，而蝰蛇毒蛋白的抗病毒机制仍有待完全阐明。禽类先天性免疫系统的研究仍处于早期阶段，导致该领域的知识零散。此外，鸟类的固有免疫和先天性免疫机制仍不清楚。
