Wei L P, Li N, Wang G, Feng X S, Lyu Z Y, Chen Y H, Chen H D, Guo L W, Chen S H, Ren J S, Shi J F, Yang W J, Wu S L, Dai M, He J
Office for Cancer Early Diagnosis and Treatment, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2018 Jul 6;52(7):685-690. doi: 10.3760/cma.j.issn.0253-9624.2018.07.002.
To investigate the association between anthropometry and colorectal cancer risk in Chinese males. Anthropometry and incident colorectal cancer cases were collected on a biennial basis starting in May 2006 among males in Kailuan Cohort (2006-2014). In addition, electronic database of hospitals affiliated to Kailuan Community, Insurance System of Kailuan Community and Tangshan were also searched for supplementary information. Cox proportional hazards regression models and linear models were used to evaluate the association between baseline anthropometry and the risk of colorectal cancer in males. A total of 106 786 males were included and 318 new colorectal cancer cases were identified in the Kailuan male cohort study, with 747 337.60 person-years follow-up by 31 December 2014. The median follow-up time was 7.90 years. Highest quartile waist circumference (≥94.0 cm) or WHtR (≥0.55) had 1.45 (95: 1.05-2.02) and 1.66 (95: 1.15-2.41) higher risk of colorectal cancer when compared with lowest waist circumference (<82.0 cm) or WHtR (<0.48) after adjusting for age, education, smoking, alcohol drinking, sitting time and dust exposure. Subgroup analyses by site indicated that males with BMI ≥26.27 kg/m(2), waist circumference ≥94.0 cm or WHtR ≥0.55 had (95) of 2.18(1.27-3.73), 2.20 (1.27-3.78) and 2.42 (1.29-4.56) for colon cancer risk, respectively. Linear models showed the of colon cancer and 95 would be 1.59 (1.24-2.02) with every 0.1 growth in WHtR. Obesity may be responsible for an increased risk of colorectal cancer in male. Reasonable weight control may be one of the effective measures to prevent colorectal cancer.
旨在探讨中国男性人体测量指标与结直肠癌风险之间的关联。自2006年5月起，每两年收集一次开滦队列男性（2006 - 2014年）的人体测量指标及新发结直肠癌病例。此外，还检索了开滦社区附属医院电子数据库、开滦社区保险系统及唐山市的相关信息以获取补充资料。采用Cox比例风险回归模型和线性模型评估基线人体测量指标与男性结直肠癌风险之间的关联。开滦男性队列研究共纳入106786名男性，截至2014年12月31日，随访318例新发结直肠癌病例，随访人年数为747337.60人年，中位随访时间为7.90年。在校正年龄、教育程度、吸烟、饮酒、久坐时间及粉尘暴露因素后，最高四分位数腰围（≥94.0 cm）或腰高比（≥0.55）的男性患结直肠癌的风险分别比最低腰围（<82.0 cm）或腰高比（<0.48）的男性高1.45倍（95%CI：1.05 - 2.02）和1.66倍（95%CI：1.15 - 2.41）。按部位进行的亚组分析表明，体重指数（BMI）≥26.27 kg/m²、腰围≥94.0 cm或腰高比≥0.55的男性患结肠癌的风险（95%CI）分别为2.18（1.27 - 3.73）、2.20（1.27 - 3.78）和2.42（1.29 - 4.56）。线性模型显示，腰高比每增加0.1，患结肠癌的风险及95%CI为1.59（1.24 - 2.02）。肥胖可能是男性结直肠癌风险增加的原因。合理控制体重可能是预防结直肠癌的有效措施之一。
