Wei L P, Li N, Wang G, Wen Y, Lyu Z Y, Feng X S, Li X, Chen Y H, Chen H D, Chen S H, Ren J S, Shi J F, Cui H, Wu S L, Dai M, He J
Office for Cancer Early Diagnosis and Treatment, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Department of Oncology, Kailuan General Hospital, Tangshan 063000, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2019 Dec 10;40(12):1522-1526. doi: 10.3760/cma.j.issn.0254-6450.2019.12.004.
To investigate the association between BMI and gastric cancer risk in Chinese males. Data on body weight, body height and incidence of gastric cancer were collected on a biennial basis in males in Kailuan Cohort during 2006-2015. In addition, electronic databases of hospitals affiliated to Kailuan Group, insurance system of Kailuan Group and medical insurance system of Tangshan were used for supplementary information. Males with normal body weight (18.5 kg/m(2)≤BMI<24.0 kg/m(2)) were used as controls. Cox proportional hazards regression model was used to evaluate the association between baseline BMI and the risk of gastric cancer in males through the calculations of hazard ratio and 95 confidence interval. A total of 109 600 males were included and 272 new gastric cancer cases were identified in Kailuan male cohort study, with a follow-up of 860 399.79 person-years during 2006-2015. The median follow-up period was 8.8 years. When compared with normal weight, the hazard ratios () of underweight (BMI≤18.5 kg/m(2)) for gastric cancer risk were 2.11 (95: 1.23-3.62) after adjusting for potential confounding factors (age, education level, smoking status, alcohol drinking status, dust exposure, salty food intake, tea drinking status). However, overweight or obesity showed no significant association with gastric cancer risk. The stratified analyses based on age, education level, status on smoking, alcohol drinking, tea drinking and dust exposure indicated that underweight showed significant association with gastric cancer risk in those with older age, those with high education level, non-smokers, non-alcohol drinkers, non-tea drinkers and those with dust exposure. Underweight might increase the risk of gastric cancer in males in China, and this positive association might be associated with age, education level, status on smoking, alcohol-drinking, tea-drink, and dust exposure.
研究中国男性体重指数（BMI）与胃癌风险之间的关联。2006年至2015年期间，开滦队列男性每两年收集一次体重、身高和胃癌发病率数据。此外，利用开滦集团下属医院的电子数据库、开滦集团保险系统和唐山市医疗保险系统获取补充信息。体重正常（18.5kg/m²≤BMI＜24.0kg/m²）的男性作为对照。采用Cox比例风险回归模型，通过计算风险比和95%置信区间，评估基线BMI与男性胃癌风险之间的关联。开滦男性队列研究共纳入109600名男性，确诊272例新发胃癌病例，2006年至2015年随访860399.79人年。中位随访期为8.8年。在校正潜在混杂因素（年龄、教育水平、吸烟状况、饮酒状况、粉尘暴露、高盐食物摄入、饮茶状况）后，与正常体重相比，体重过低（BMI≤18.5kg/m²）患胃癌风险的风险比（HR）为2.11（95%CI：1.23 - 3.62）。然而，超重或肥胖与胃癌风险无显著关联。基于年龄、教育水平、吸烟、饮酒、饮茶和粉尘暴露的分层分析表明，体重过低在年龄较大、教育水平较高、不吸烟者、不饮酒者、不饮茶者和有粉尘暴露者中与胃癌风险显著相关。体重过低可能会增加中国男性患胃癌的风险，这种正相关可能与年龄、教育水平、吸烟、饮酒、饮茶和粉尘暴露有关。
