Li X S, Zhang M C, Qu Y C, Zhang X Q, Pan F, Liu Y X
Department of Radiology, the Chinese-Japan Union Hospitai of Jilin University, Changchun 130033, China.
Zhonghua Gan Zang Bing Za Zhi. 2018 Apr 20;26(4):294-297. doi: 10.3760/cma.j.issn.1007-3418.2018.04.012.
To investigate the imaging diagnosis, treatment and prognosis of primary hepatic neuroendocrine tumors. The clinical features, imaging manifestations, histopathological and immunohistochemical findings and interventional therapy of 6 patients identified with pathologically confirmed primary hepatic neuroendocrine tumors were retrospectively analyzed, and the related literatures were reviewed. All 6 patients presented with symptoms of abdominal pain. 4 patients had solitary hepatic mass and 2 patients had multiple hepatic masses. Magnetic resonance imaging showed low signal intensity on T1 weighted imaging, high signal intensity on T2 weighted imaging and clear boundary; the arterial phase of enhancement scan was uneven and enhanced, and portal venous phase or delayed phase showed continuous enhancement, surrounded by ring enhanced capsule. A pathological diagnosis was primary neuroendocrine tumor of the liver. After interventional treatment, 6 patients had some therapeutic effects. Among them, 4 patients underwent multiple interventional therapies, followed by 4 years of follow-up has shown satisfactory results. Primary hepatic neuroendocrine tumors are very rare and their imaging manifestations are specific. Eventually, relies on pathological and immunohistochemical diagnosis. Transarterial chemoembolization therapy can bring satisfactory results in the treatment of primary hepatic neuroendocrine tumor.
探讨原发性肝脏神经内分泌肿瘤的影像诊断、治疗及预后。回顾性分析6例经病理确诊的原发性肝脏神经内分泌肿瘤患者的临床特征、影像表现、组织病理学及免疫组化结果以及介入治疗情况，并复习相关文献。6例患者均有腹痛症状。4例患者有肝脏单发肿块，2例患者有肝脏多发肿块。磁共振成像表现为T1加权像呈低信号，T2加权像呈高信号，边界清晰；增强扫描动脉期不均匀强化，门静脉期或延迟期呈持续强化，周边有环形强化包膜。病理诊断为肝脏原发性神经内分泌肿瘤。介入治疗后，6例患者均有一定治疗效果。其中4例患者接受了多次介入治疗，随访四年结果满意。原发性肝脏神经内分泌肿瘤非常罕见，其影像表现具有特异性。最终，依靠病理及免疫组化诊断。经动脉化疗栓塞治疗可给原发性肝脏神经内分泌肿瘤的治疗带来满意效果。
