Department of Hepatobiliary-Pancreatic-Splenic Surgery, Inner Mongolia Autonomous Region People's Hospital, 20 Zhao Wu Da Road, Hohhot 010017, China.
Department of Biliary-Pancreatic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China.
J Int Med Res. 2020 Jun;48(6):300060520932114. doi: 10.1177/0300060520932114.
Primary hepatic neuroendocrine tumors (PHNETs) are a group of extremely rare tumors that are difficult to differentiate from common hepatic malignancies on routine imaging studies. By presenting a case of PHNET, we herein introduce our experience with the diagnosis, differential diagnosis, and management of patients with this rare disease. The patient was preoperatively diagnosed with hepatic hydatidosis but postoperatively diagnosed with a PHNET with multiple liver metastases. He was successfully treated with transcatheter arterial chemoembolization. This case indicates that the clinical diagnosis of PHNET is a medical challenge. Although peptide receptor radionuclide therapy has been suggested as the mainstay of treatment for well-differentiated somatostatin receptor-positive PHNETs, patients with a large tumor burden may also benefit from transcatheter arterial chemoembolization.
原发性肝神经内分泌肿瘤（PHNET）是一组极为罕见的肿瘤，在常规影像学研究中很难与常见的肝恶性肿瘤区分开来。通过介绍 1 例 PHNET 病例，我们介绍了我们在诊断、鉴别诊断和治疗这种罕见疾病方面的经验。该患者术前诊断为肝包虫病，但术后诊断为多发性肝转移的 PHNET。他成功地接受了经导管肝动脉化疗栓塞术治疗。该病例表明，PHNET 的临床诊断是一个医学挑战。尽管肽受体放射性核素治疗已被建议作为分化良好的生长抑素受体阳性 PHNET 的主要治疗方法，但肿瘤负荷较大的患者也可能受益于经导管肝动脉化疗栓塞术。
