Stamford J A, Kruk Z L, Millar J
Neurosci Lett. 1985 Oct 10;60(3):357-62. doi: 10.1016/0304-3940(85)90603-2.
Electrical stimulation of the nigrostriatal pathway released dopamine (DA) in the striatum of the anaesthetized rat. The level of DA released by 10-s stimulus trains was measured by high-speed cyclic voltammetry. Metoclopramide (10 mg/kg) increased DA release by approximately 20%. Apomorphine (1.76 mg/kg) caused a approximately 40% decrease in release which was blocked by metoclopramide. Ascorbate (1.76 g/kg) had no effect on stimulated DA release. Furthermore, pretreatment of rats with ascorbate trebled the striatal extracellular ascorbate level, but failed to modify the effects of metoclopramide and apomorphine on DA release. We conclude that ascorbate has no effect on the presynaptic autoreceptors that modulate striatal DA release in vivo.
对麻醉大鼠的黑质纹状体通路进行电刺激可使纹状体内释放多巴胺（DA）。通过高速循环伏安法测定10秒刺激序列释放的DA水平。甲氧氯普胺（10 mg/kg）使DA释放增加约20%。阿扑吗啡（1.76 mg/kg）使释放量减少约40%，这一作用被甲氧氯普胺阻断。抗坏血酸（1.76 g/kg）对刺激引起的DA释放无影响。此外，用抗坏血酸预处理大鼠可使纹状体细胞外抗坏血酸水平增加两倍，但未能改变甲氧氯普胺和阿扑吗啡对DA释放的影响。我们得出结论，抗坏血酸对体内调节纹状体DA释放的突触前自身受体无影响。
