Stamford J A, Kruk Z L, Millar J
Department of Pharmacology, London Hospital Medical College, U.K.
Neurosci Lett. 1987 Nov 23;82(2):172-6. doi: 10.1016/0304-3940(87)90124-8.
The frequency response of nigrostriatal neurones to electrical stimulation of the median forebrain bundle was investigated in vivo using high-speed cyclic voltammetry to measure the evoked striatal dopamine overflow. It was found that the nerves could follow 25-50 Hz stimulation for at least 10 s, whereas the neurones were unable to respond to high frequencies (100-200 Hz) for more than 1-3 s. Accommodation, due to incomplete re-equilibration of ionic fluxes between successive stimuli, provides a possible explanation for these findings.
利用高速循环伏安法测量诱发的纹状体多巴胺溢出，在体内研究黑质纹状体神经元对正中前脑束电刺激的频率响应。结果发现，神经能够跟随25 - 50赫兹的刺激至少10秒，而神经元对高频（100 - 200赫兹）的反应不能超过1 - 3秒。由于连续刺激之间离子通量的不完全重新平衡导致的适应，为这些发现提供了一种可能的解释。
