Yamada Hodaka, Funazaki Shunsuke, Suzuki Daisuke, Saikawa Rika, Yoshida Masashi, Kakei Masafumi, Ishikawa San-E, Morisita Yoshiyuki, Hara Kazuo
Department of Medicine, Division of Endocrinology and Metabolism, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan.
Division of Endocrinology and Metabolism, International University of Health and Welfare Hospital, 537-3 Iguchi, Nasushiobara, Tochigi 329-2763, Japan.
J Clin Med. 2018 Jul 10;7(7):171. doi: 10.3390/jcm7070171.
Urinary calcium excretion is not known to predict progression of renal dysfunction in patients with type 2 diabetes mellitus. This study aimed to investigate associations between urinary calcium excretion and progression of estimated glomerular filtration rate (eGFR) in type 2 diabetic patients. This study was a retrospective, single-center, observational cohort study. We enrolled a total of 89 patients with type 2 diabetes mellitus and the average follow-up period was 7.2 ± 1.0 years. We divided patients into two groups based on the median of annual decline in the slope of eGFR, then defined the over-median population as the progressed group and under-median population as the non-progressed group. Median of annual decline in the slope of eGFR was −1.1 mL/min/1.73 m²/year. Correlation coefficient analysis showed positive correlation of urinary calcium excretion with eGFR ( = 0.39, < 0.001). Multivariate logistic analysis showed that baseline eGFR and urinary calcium excretion were independent variables for progression of eGFR decline. Urinary calcium excretion could be a useful metabolic parameter for predicting decline in slope of eGFR in patients with type 2 diabetes mellitus.
目前尚不清楚尿钙排泄能否预测2型糖尿病患者肾功能不全的进展。本研究旨在调查2型糖尿病患者尿钙排泄与估计肾小球滤过率（eGFR）进展之间的关联。本研究为一项回顾性、单中心观察性队列研究。我们共纳入了89例2型糖尿病患者，平均随访时间为7.2±1.0年。我们根据eGFR斜率的年下降中位数将患者分为两组，然后将高于中位数的人群定义为进展组，低于中位数的人群定义为非进展组。eGFR斜率的年下降中位数为−1.1 mL/min/1.73 m²/年。相关系数分析显示尿钙排泄与eGFR呈正相关（=0.39，<0.001）。多因素逻辑分析显示，基线eGFR和尿钙排泄是eGFR下降进展的独立变量。尿钙排泄可能是预测2型糖尿病患者eGFR斜率下降的有用代谢参数。
