Moor Matthias B, Bonny Olivier
Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland; and.
Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland; and Service of Nephrology, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland
Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1337-50. doi: 10.1152/ajprenal.00273.2015. Epub 2016 Mar 23.
The role of the kidney in calcium homeostasis has been reshaped from a classic view in which the kidney was regulated by systemic calcitropic hormones such as vitamin D3 or parathyroid hormone to an organ actively taking part in the regulation of calcium handling. With the identification of the intrinsic renal calcium-sensing receptor feedback system, the regulation of paracellular calcium transport involving claudins, and new paracrine regulators such as klotho, the kidney has emerged as a crucial modulator not only of calciuria but also of calcium homeostasis. This review summarizes recent molecular and endocrine contributors to renal calcium handling and highlights the tight link between calcium and sodium reabsorption in the kidney.
肾脏在钙稳态中的作用已从传统观点发生了重塑，传统观点认为肾脏受维生素D3或甲状旁腺激素等全身钙调节激素的调控，而现在肾脏已成为积极参与钙处理调节的器官。随着肾脏内在钙敏感受体反馈系统的发现、涉及紧密连接蛋白的细胞旁钙转运调节以及诸如klotho等新的旁分泌调节因子的发现，肾脏不仅已成为尿钙排泄的关键调节因子，而且也成为钙稳态的关键调节因子。本综述总结了近期对肾脏钙处理有贡献的分子和内分泌因素，并强调了肾脏中钙重吸收与钠重吸收之间的紧密联系。
