神经垂体肽抑制哺乳动物交感神经节中的胆碱能传递。

Neurohypophysial peptides depress cholinergic transmission in a mammalian sympathetic ganglion.

作者信息

Kiraly M, Maillard M, Dreifuss J J, Dolivo M

出版信息

Neurosci Lett. 1985 Nov 20;62(1):89-95. doi: 10.1016/0304-3940(85)90289-7.

Abstract

The actions of arginine-vasopressin (AVP) and oxytocin (OXT) were investigated in the rat superior cervical ganglion (SCG). At micromolar concentrations AVP decreased the amplitude of fast excitatory postsynaptic potentials (f-EPSPs) evoked by preganglionic stimulation and in many cells depolarized the postsynaptic membrane. Both effects were reversibly abolished by a potent vasopressor antagonist. The peptide decreased the frequency of spontaneous miniature EPSPs and the quantal content of the f-EPSPs without affecting the sensitivity of the ganglion cells to acetylcholine. OXT exerted the same effects as AVP but was less powerful. It was concluded that neurohypophysial peptides exert a dual pre- and post-synaptic action mediated by specific receptors.

摘要

在大鼠颈上神经节（SCG）中研究了精氨酸加压素（AVP）和催产素（OXT）的作用。在微摩尔浓度下，AVP降低了节前刺激诱发的快速兴奋性突触后电位（f-EPSP）的幅度，并且在许多细胞中使突触后膜去极化。这两种效应均被一种强效血管升压拮抗剂可逆性消除。该肽降低了自发微小EPSP的频率和f-EPSP的量子含量，而不影响神经节细胞对乙酰胆碱的敏感性。OXT发挥了与AVP相同的作用，但作用较弱。得出的结论是，神经垂体肽通过特定受体发挥突触前和突触后的双重作用。