Harchegani Asghar Beigi, Rahmani Alireza, Tahmasbpour Eisa, Kabootaraki Hamid Bakhiari, Rostami Hossein, Shahriary Alireza
1 Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
4 Laboratory of Regenerative Medicine and Biomedical Innovations, Pasteur Institute of Iran, Tehran, Iran.
Toxicol Ind Health. 2018 Sep;34(9):653-664. doi: 10.1177/0748233718778665. Epub 2018 Jul 11.
Diazinon (DZN) is an organophosphate insecticide that has cytotoxic and pathological effects on the reproductive system. It causes a wide variety of pathological effects on the reproductive system such as testicular atrophy, disturbance in sex hormones, impaired spermatogenesis, low quality of sperm, and fertility problems. However, molecular and cellular mechanisms of its adverse effects are not well understood. General events such as testicular damage, inflammation, mitochondrial deficiency, DNA fragmentation, disintegration of sperm plasma membrane, apoptosis, and cell death are observed in DZN-exposed animals. Oxidative stress (OS) induced by reactive oxygen species may be a main mechanism, which can be associated with sperm DNA fragmentation, reduced integrity of sperm cell membrane, apoptosis, depletion of antioxidants, and subsequently poor sperm quality and male infertility. Therefore, identification of these pathways may provide valuable information regarding the mechanisms of DZN action on the male reproductive system. In this review, we aim to discuss the proposed cellular and molecular mechanisms of DZN action on male reproductive system, the importance of OS and mechanisms by which DZN induces OS and depletion of other antioxidants.
二嗪农（DZN）是一种有机磷酸酯类杀虫剂，对生殖系统具有细胞毒性和病理作用。它会对生殖系统造成多种病理影响，如睾丸萎缩、性激素紊乱、精子发生受损、精子质量低下以及生育问题。然而，其不良反应的分子和细胞机制尚未完全明确。在暴露于二嗪农的动物中可观察到诸如睾丸损伤、炎症、线粒体缺陷、DNA片段化、精子质膜解体、细胞凋亡和细胞死亡等一般事件。活性氧诱导的氧化应激（OS）可能是主要机制，这可能与精子DNA片段化、精子细胞膜完整性降低、细胞凋亡、抗氧化剂耗竭以及随后的精子质量差和男性不育有关。因此，确定这些途径可能为二嗪农对雄性生殖系统的作用机制提供有价值的信息。在本综述中，我们旨在讨论二嗪农对雄性生殖系统作用的细胞和分子机制、氧化应激以及二嗪农诱导氧化应激和其他抗氧化剂耗竭的机制的重要性。
