Chali Sima Ebadi Naft, Khanbabaei Ramzan, Juybari Abbas Ali Dehpour, Fatahi Esmail, Kalai Roya Bisheh
Department of Biology, Qaemshahr Branch, Islamic Azad University, Qaemshahr 3149968111, Iran.
Toxicol Res (Camb). 2023 Mar 11;12(2):264-269. doi: 10.1093/toxres/tfad012. eCollection 2023 Apr.
Prenatal acute and chronic exposure to organophosphorus pesticides may evoke physical and behavioral impairments in offspring development. However, the mechanism of antioxidant consumption repair to cure these impairments remains unclear. This study aimed to investigate the protective effects of COQ10 against DZN toxicity by measuring Malondialdehyde (MDA) level, superoxide dismutase (SOD) activity, the expression of MH2A, DNMT1, H2AZ, and HDAC3, and the histopathology in the brain of neonatal Wistar albino rats whose male parents were exposed to DZN and COQ10. The results showed that COQ10 could significantly decrease MDA level, histopathological alteration, and expression of DNMT1 and HDAC3 in the neonatal brain ( < 0.05). Also, an increase in SOD activity and expression of MH2A and H2AZ were observed in the neonatal brain of this group ( < 0.05). These investigations suggest that COQ10 can reduce the effects of DZN on neuronal oxidative stress and its damage to the neonatal brain.
产前急性和慢性暴露于有机磷农药可能会在子代发育过程中引发身体和行为损伤。然而，抗氧化剂消耗修复以治愈这些损伤的机制仍不清楚。本研究旨在通过测量丙二醛（MDA）水平、超氧化物歧化酶（SOD）活性、MH2A、DNMT1、H2AZ和HDAC3的表达以及雄性亲本暴露于敌百虫（DZN）和辅酶Q10（COQ10）的新生Wistar白化大鼠大脑的组织病理学，来研究COQ10对敌百虫毒性的保护作用。结果表明，COQ10可显著降低新生大鼠大脑中的MDA水平、组织病理学改变以及DNMT1和HDAC3的表达（P<0.05）。此外，该组新生大鼠大脑中还观察到SOD活性以及MH2A和H2AZ表达增加（P<0.05）。这些研究表明，COQ10可以减轻DZN对神经元氧化应激的影响及其对新生大鼠大脑的损伤。
