Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, USA.
Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, USA.
J Int Soc Sports Nutr. 2018 Jul 11;15(1):32. doi: 10.1186/s12970-018-0238-7.
Sarcopenia, a reduction in muscle mass and function seen in aging populations, may be countered by improving systemic carnosine stores via beta-Alanine (β-alanine) supplementation. Increasing systemic carnosine levels may result in enhanced anti-oxidant, neuro-protective and pH buffering capabilities. This enhancement should result in improved exercise capacity and executive function.
Twelve healthy adults (average age = 60.5 ± 8.6 yrs, weight = 81.5 ± 12.6 kg) were randomized and given either 2.4 g/d of β-alanine (BA) or Placebo (PL) for 28 days. Exercise capacity was tested via bouts on a cycle ergometer at 70% VO peak. Executive function was measured by Stroop Tests 5 min before exercise (T1), immediately before exercise (T2), immediately following fatigue (T3), and 5 min after fatigue (T4). Lactate measures were taken pre/post exercise. Heart rate, Rating of Perceived Exertion (RPE) and VO were recorded throughout exercise testing.
PRE average time-to-exhaustion (TTE) for the PL and BA group were not significantly different (Mean ± SD; 9.4 ± 1.4mins vs 11.1 ± 2.4mins, respectively, P = 0.7). POST BA supplemented subjects cycled significantly longer than PRE (14.6 ± 3.8mins vs 11.1 ± 2.4mins, respectively, P = 0.04) while those given PL did not (8.7 ± 2.4mins vs 9.4 ± 1.4mins, respectively, P = 0.7). PL subjects were slower in completing the Stroop test POST at T4 compared to T3 (T3 = - 13.3 ± 8.6% vs T4 = 2.1 ± 8.3%, P = 0.04), while the BA group (T3 = - 9.2 ± 6.4% vs T4 = - 2.5 ± 3.5%, P = 0.5) was not. POST lactate production expressed a trend when comparing treatments, as the BA group produced 2.4 ± 2.6 mmol/L more lactate than the PL group (P = 0.06). Within group lactate production for BA (P = 0.4) and PL (P = 0.5), RPE (P = 0.9) and heart rate (P = 0.7) did not differ with supplementation.
BA supplementation increased exercise capacity and eliminated endurance exercise induced declines in executive function seen after recovery. Increased POST TTE coupled with similar PRE vs POST lactate production indicates an improvement in the ability of BA to extend exercise durations. Furthermore, by countering endurance exercise's accompanying deficits in executive function, the aging population can maintain benefits from exercise with improved safety.
肌肉减少症是一种在老年人群中出现的肌肉质量和功能下降的现象，可以通过提高β-丙氨酸（β-alanine，β-丙氨酸）补充剂的全身肌肽储存来对抗。增加全身肌肽水平可能会导致增强抗氧化、神经保护和 pH 缓冲能力。这种增强应该会导致运动能力和执行功能的提高。
12 名健康成年人（平均年龄 60.5±8.6 岁，体重 81.5±12.6 公斤）被随机分为 2.4 克/天的 β-丙氨酸（BA）或安慰剂（PL）组，进行 28 天的补充。运动能力通过在循环测力计上以 70%的峰值 VO2 进行测试。执行功能通过斯特鲁普测试进行测量，在运动前 5 分钟（T1）、运动前即刻（T2）、疲劳后即刻（T3）和疲劳后 5 分钟（T4）进行。运动前后测量乳酸。运动测试过程中记录心率、主观用力程度（RPE）和 VO2。
PL 和 BA 组的 PRE 平均疲劳时间（TTE）没有显著差异（Mean±SD；分别为 9.4±1.4 分钟和 11.1±2.4 分钟，P=0.7）。BA 补充组 POST 时的骑行时间明显长于 PRE（分别为 14.6±3.8 分钟和 11.1±2.4 分钟，P=0.04），而 PL 组没有（分别为 8.7±2.4 分钟和 9.4±1.4 分钟，P=0.7）。PL 组在 POST 的 T4 时完成斯特鲁普测试的速度比 T3 时慢（T3=-13.3±8.6%，T4=2.1±8.3%，P=0.04），而 BA 组（T3=-9.2±6.4%，T4=-2.5±3.5%，P=0.5）则没有。与治疗相比，POST 时的乳酸生成呈趋势，BA 组产生的乳酸比 PL 组多 2.4±2.6mmol/L（P=0.06）。BA（P=0.4）和 PL（P=0.5）组的组内乳酸生成、RPE（P=0.9）和心率（P=0.7）在补充后没有差异。
BA 补充剂增加了运动能力，并消除了耐力运动后恢复时执行功能的下降。POST TTE 的增加，加上 PRE 和 POST 时相似的乳酸生成，表明 BA 延长运动时间的能力有所提高。此外，通过对抗耐力运动伴随的执行功能缺陷，老年人群可以通过提高安全性来保持运动的益处。
Zotero 插件
